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Type: Journal article
Title: Cytolytic perforin as an adjuvant to enhance the immunogenicity of DNA vaccines
Author: Shrestha, A.C.
Wijesundara, D.K.
Masavuli, M.G.
Mekonnen, Z.A.
Gowans, E.J.
Grubor-Bauk, B.
Citation: Vaccines, 2019; 7(2)
Publisher: MDPI
Issue Date: 2019
ISSN: 2076-393X
Statement of
Ashish C. Shrestha, Danushka K. Wijesundara, Makutiro G. Masavuli, Zelalem A. Mekonnen, Eric J. Gowans and Branka Grubor-Bauk
Abstract: DNA vaccines present one of the most cost-effective platforms to develop global vaccines, which have been tested for nearly three decades in preclinical and clinical settings with some success in the clinic. However, one of the major challenges for the development of DNA vaccines is their poor immunogenicity in humans, which has led to refinements in DNA delivery, dosage in prime/boost regimens and the inclusion of adjuvants to enhance their immunogenicity. In this review, we focus on adjuvants that can enhance the immunogenicity of DNA encoded antigens and highlight the development of a novel cytolytic DNA platform encoding a truncated mouse perforin. The application of this innovative DNA technology has considerable potential in the development of effective vaccines
Keywords: DNA vaccine; adjuvants; vaccine delivery; plasmid; cytolytic; perforin; bicistronic; HCV; HIV
Rights: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
DOI: 10.3390/vaccines7020038
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