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https://hdl.handle.net/2440/121557
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Type: | Journal article |
Title: | Erectile dysfunction is independently associated with apnea-hypopnea index and oxygen desaturation index in elderly, but not younger, community-dwelling men |
Author: | Martin, S.A. Appleton, S.L. Adams, R.J. Taylor, A.W. Vincent, A. Brook, N.R. Catcheside, P.G. Vakulin, A. McEvoy, R.D. Antic, N.A. Wittert, G.A. |
Citation: | Sleep Health, 2017; 3(4):250-256 |
Publisher: | Elsevier |
Issue Date: | 2017 |
ISSN: | 2352-7218 2352-7218 |
Statement of Responsibility: | Sean A. Martin, Sarah L. Appleton, Robert J. Adams, AnneW. Taylor, Andrew Vincent, Nicholas R. Brook, Peter G. Catcheside, Andrew Vakulin, Douglas McEvoy, Nick A. Antic, Gary A. Wittert |
Abstract: | To examine the association between obstructive sleep apnea (OSA) and other sleep indices using polysomnography (PSG) data and erectile dysfunction (ED) in a representative cohort of men.Cross-sectional.Community-based.Aged 40+ years (n=734; mean age [SD], 60.8 [10.9]).Men with no prior OSA diagnosis who underwent in-home PSG (Embletta X100; 2010-11) and ED assessment (Global Impotence Rating) were selected. Un-adjusted and multi-adjusted regression models of ED were fitted against PSG measures, along with qualifying sociodemographic, lifestyle, and health-related covariates. Mediation effects were examined using the Baron-Kenny method.Of the men examined, 24.7% (n=181) had ED, most notably in men older than 65years (cf. men 35-49 and 50-64years; P<.001). There was no significant association between ED and any of the PSG measures for allaged men. Given an observed ageinteraction within OSA categories (P=.005), analyses were repeated in age-stratified samples (<65 years; 65+ years). In men younger than 65years, only severe OSA was found to have an association with ED (2.01; 1.13-4.69) in unadjusted models. For men aged 65+ years, an independent association with ED was found for apnea-hyponea index (AHI; 1.55;1.02-2.36), moderate (AHI:10.0-19.9; 1.79;1.18-2.43), and severe (AHI:20.0+; 4.84;2.56-9.93) OSA, and oxygen desaturation index (ODI; both continuous [1.48;1.03-1.99] and >16 seconds [2.79;1.23-6.32]). The effect of AHI on ED was shown to be primarily mediated through ODI (63.4%, Sobel P value=.29).In younger, community-based men, there appeared no independent relationship between objective measures of sleep and ED. However, there appears a strong, independent relationship between OSA, ODI, and ED in men 65 years and older. |
Keywords: | Humans Sleep Apnea, Obstructive Oxygen Polysomnography Severity of Illness Index Risk Factors Cohort Studies Cross-Sectional Studies Age Factors Middle Aged Male Erectile Dysfunction Independent Living |
Rights: | © 2017 National Sleep Foundation. Published by Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.sleh.2017.04.006 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/627227 |
Published version: | http://dx.doi.org/10.1016/j.sleh.2017.04.006 |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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