Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/121587
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Watson, L.E. | - |
dc.contributor.author | Xie, C. | - |
dc.contributor.author | Wang, X. | - |
dc.contributor.author | Li, Z. | - |
dc.contributor.author | Phillips, L.K. | - |
dc.contributor.author | Sun, Z. | - |
dc.contributor.author | Jones, K.L. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Rayner, C.K. | - |
dc.contributor.author | Wu, T. | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Journal of Clinical Endocrinology and Metabolism, 2019; 104(8):3311-3319 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.issn | 1945-7197 | - |
dc.identifier.uri | http://hdl.handle.net/2440/121587 | - |
dc.description.abstract | CONTEXT:Gastric emptying is a major determinant of postprandial glycemia and is often delayed in long-standing, complicated type 2 diabetes mellitus (T2DM). However, there is little information about gastric emptying in well-controlled T2DM. OBJECTIVE:To evaluate the rate of gastric emptying in community-based patients with relatively well-controlled T2DM compared with young and older control subjects without diabetes. PARTICIPANTS AND DESIGN:A total of 111 patients with T2DM managed by diet (n = 52) or metformin monotherapy (n = 59) (HbA1c 6.6 ± 0.1%/49.0 ± 0.9 mmol/mol), 18 age- and body mass index (BMI)-matched older subjects without diabetes, and 15 young healthy subjects consumed a standardized mashed potato meal (368.5 kcal) containing 100 μL 13C-octanoic acid. Gastric emptying (by breath test) and blood glucose were evaluated over 240 minutes. RESULTS:Gastric emptying was slower in the older than in the young subjects without diabetes (2.3 ± 0.1 vs 3.0 ± 0.1 kcal/min, P = 0.0008). However, relative to the age- and BMI-matched subjects without diabetes, gastric emptying (2.8 ± 0.1 kcal/min) was faster in patients with T2DM (P = 0.0005). Furthermore, gastric emptying was faster in the metformin-treated (3.0 ± 0.1 kcal/min) than in the diet-controlled (2.7 ± 0.1 kcal/min) patients with T2DM (P = 0.011), although there were no differences in age, BMI, HbA1c, or the duration of known diabetes. The increments in blood glucose (at t = 30 and 60 minutes and the incremental area under the curve during t = 0 to 120 minutes) after the meal were related directly to the rate of gastric emptying in the subjects with T2DM regardless of treatment with or without metformin (P < 0.05 each). CONCLUSIONS:Gastric emptying is slowed with aging but otherwise is relatively more rapid in patients with well-controlled T2DM. This provides a strong rationale for slowing gastric emptying to improve postprandial glycemic control in these patients. | - |
dc.description.statementofresponsibility | Linda E Watson, Cong Xie, Xuyi Wang, Ziyi Li, Liza K Phillips, Zilin Sun, Karen L Jones, Michael Horowitz, Christopher K Rayner, Tongzhi Wu | - |
dc.language.iso | en | - |
dc.publisher | Endocrine Society | - |
dc.rights | © 2019 Endocrine Society | - |
dc.source.uri | http://dx.doi.org/10.1210/jc.2018-02736 | - |
dc.subject | Humans | - |
dc.subject | Diabetes Mellitus, Type 2 | - |
dc.subject | Metformin | - |
dc.subject | Hypoglycemic Agents | - |
dc.subject | Age Factors | - |
dc.subject | Aging | - |
dc.subject | Gastric Emptying | - |
dc.subject | Postprandial Period | - |
dc.subject | Adolescent | - |
dc.subject | Adult | - |
dc.subject | Aged | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Young Adult | - |
dc.subject | Independent Living | - |
dc.subject | Diet, Diabetic | - |
dc.title | Gastric emptying in patients with well-controlled type 2 diabetes compared with young and older control subjects without diabetes | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1210/jc.2018-02736 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1066835 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Xie, C. [0000-0002-0054-9269] | - |
dc.identifier.orcid | Phillips, L.K. [0000-0002-9066-717X] | - |
dc.identifier.orcid | Jones, K.L. [0000-0002-1155-5816] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Rayner, C.K. [0000-0002-5527-256X] | - |
dc.identifier.orcid | Wu, T. [0000-0003-1656-9210] | - |
Appears in Collections: | Aurora harvest 8 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.