Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/121659
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pansara, C. | - |
dc.contributor.author | Chan, W.Y. | - |
dc.contributor.author | Parikh, A. | - |
dc.contributor.author | Trott, D.J. | - |
dc.contributor.author | Mehta, T. | - |
dc.contributor.author | Mishra, R. | - |
dc.contributor.author | Garg, S. | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Journal of Pharmaceutical Sciences, 2019; 108(2):1007-1016 | - |
dc.identifier.issn | 0022-3549 | - |
dc.identifier.issn | 1520-6017 | - |
dc.identifier.uri | http://hdl.handle.net/2440/121659 | - |
dc.description.abstract | Antimicrobial resistance at the infected site is a serious medical issue that increases patient morbidity and mortality. Silver has antibacterial activity associated with some dose-dependent toxicity. Silver nanoparticles, due to larger surface area, have antibacterial properties, which make them useful in the treatment of infections. Chitosan-stabilized silver nanoparticles (CH-AgNP) were formulated and evaluated for minimal inhibitory concentration and minimal bactericidal concentration testing against Staphylococcus aureus ATCC 29213, S aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922, and 20 methicillin-resistant S aureus isolates. Minimum biofilm eradication concentration study was used to evaluate the biofilm reduction, and in vitro antimicrobial checkerboard assays were performed. The effective optimum ratio of AgNP:chitosan solution was 1:4. Minimal inhibitory concentration and minimal bactericidal concentration ranges of CH-AgNP were 4 to 14 times lower compared to AgNP alone against methicillin-resistant S aureus isolates. Minimum biofilm eradication concentration values of CH-AgNP for ATCC PA-01, P aeruginosa isolate 1, and P aeruginosa isolate 2 were found to be >84.59 μg/mL, 42.29 μg/mL, and 21.15 μg/mL, respectively. Thus, CH-AgNP is a potential formulation for wound treatment and management of infected sites associated with antimicrobial resistance. | - |
dc.description.statementofresponsibility | Chintan Pansara, Wei Yee Chan, Ankit Parikh, Darren J. Trott, Tejal Mehta, Renuka Mishra, Sanjay Garg | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | © 2019 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.xphs.2018.09.011 | - |
dc.subject | Chitosan; silver; chitosan-silver nanoparticles; antibacterial activity; minimum inhibitory concentration; minimum bactericidal activity; biofilm minimum biofilm eradication concentration assay | - |
dc.title | Formulation optimization of chitosan-stabilized silver nanoparticles using in vitro antimicrobial assay | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.xphs.2018.09.011 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Chan, W.Y. [0000-0002-9415-9893] | - |
dc.identifier.orcid | Trott, D.J. [0000-0002-8297-5770] | - |
Appears in Collections: | Animal and Veterinary Sciences publications Aurora harvest 8 |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.