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https://hdl.handle.net/2440/122917
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Type: | Journal article |
Title: | Oxylipins and free fatty acids in parenteral lipid emulsions currently used in preterm infant care: an in vitro study |
Author: | Suganuma, H. Collins, C.T. McPhee, A.J. Liu, G. Gibson, R.A. |
Citation: | Journal of Pediatric Gastroenterology and Nutrition, 2019; 69(2):231-234 |
Publisher: | Wolters Kluwer |
Issue Date: | 2019 |
ISSN: | 0277-2116 1536-4801 |
Statement of Responsibility: | Hiroki Suganuma, Carmel T. Collins, Andrew J. McPhee, Ge Liu, and Robert A. Gibson |
Abstract: | Lipid emulsions used to support nutrition in preterm infants contain long-chain polyunsaturated fatty acids (LCPUFAs) as a source of essential fatty acids; these LCPUFAs and their parent polyunsaturated fatty acid (PUFA) can be oxidized by a variety of mechanisms to bioactive molecules called oxylipins, which are signaling molecules that initiate and/or resolve inflammation. The aim of this study was to explore levels of free LCPUFA and their related oxylipins in 3 commercially available lipid emulsions (Intralipid, SMOFlipid, and ClinOleic) using ultra high-performance liquid chromatography mass spectroscopy. Free LCPUFA were detected in all lipid emulsions tested. Seven, 8, and 9 different oxylipin compounds were detected in the 3 emulsions, respectively. The oxylipins detected were mainly derived from omega-6 PUFAs; these included 13-hydroxyoctadecadienoic acid from linoleic acid and 5-hydroxyeicosatetraenoic acid derived from arachidonic acid. It may be clinically important to know that oxylipins exist in lipid emulsions and to evaluate their potential effects on preterm infants. |
Keywords: | Arachidonic acid; linoleic acid; oxidation; polyunsaturated fatty acid |
Rights: | © 2019 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition |
DOI: | 10.1097/mpg.0000000000002369 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1132596 http://purl.org/au-research/grants/nhmrc/1046207 |
Published version: | http://dx.doi.org/10.1097/mpg.0000000000002369 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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