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Type: Journal article
Title: Oxylipins and free fatty acids in parenteral lipid emulsions currently used in preterm infant care: an in vitro study
Author: Suganuma, H.
Collins, C.T.
McPhee, A.J.
Liu, G.
Gibson, R.A.
Citation: Journal of pediatric gastroenterology and nutrition, 2019; 69(2):231-234
Publisher: Wolters Kluwer
Issue Date: 2019
ISSN: 0277-2116
Statement of
Hiroki Suganuma, Carmel T. Collins, Andrew J. McPhee, Ge Liu, and Robert A. Gibson
Abstract: Lipid emulsions used to support nutrition in preterm infants contain long-chain polyunsaturated fatty acids (LCPUFAs) as a source of essential fatty acids; these LCPUFAs and their parent polyunsaturated fatty acid (PUFA) can be oxidized by a variety of mechanisms to bioactive molecules called oxylipins, which are signaling molecules that initiate and/or resolve inflammation. The aim of this study was to explore levels of free LCPUFA and their related oxylipins in 3 commercially available lipid emulsions (Intralipid, SMOFlipid, and ClinOleic) using ultra high-performance liquid chromatography mass spectroscopy. Free LCPUFA were detected in all lipid emulsions tested. Seven, 8, and 9 different oxylipin compounds were detected in the 3 emulsions, respectively. The oxylipins detected were mainly derived from omega-6 PUFAs; these included 13-hydroxyoctadecadienoic acid from linoleic acid and 5-hydroxyeicosatetraenoic acid derived from arachidonic acid. It may be clinically important to know that oxylipins exist in lipid emulsions and to evaluate their potential effects on preterm infants.
Keywords: Arachidonic acid; linoleic acid; oxidation; polyunsaturated fatty acid
Rights: © 2019 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition
RMID: 0030113877
DOI: 10.1097/mpg.0000000000002369
Grant ID:
Appears in Collections:Medicine publications

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