Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/124136
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dc.contributor.author | Simmonds, L.A. | - |
dc.contributor.author | Sullivan, T.R. | - |
dc.contributor.author | Skubisz, M. | - |
dc.contributor.author | Middleton, P.F. | - |
dc.contributor.author | Best, K.P. | - |
dc.contributor.author | Yelland, L.N. | - |
dc.contributor.author | Quinlivan, J. | - |
dc.contributor.author | Zhou, S.J. | - |
dc.contributor.author | Liu, G. | - |
dc.contributor.author | McPhee, A.J. | - |
dc.contributor.author | Gibson, R.A. | - |
dc.contributor.author | Makrides, M. | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | BJOG: an International Journal of Obstetrics and Gynaecology, 2020; 127(8):975-981 | - |
dc.identifier.issn | 1470-0328 | - |
dc.identifier.issn | 1471-0528 | - |
dc.identifier.uri | http://hdl.handle.net/2440/124136 | - |
dc.description | First published:08 February 2020 | - |
dc.description.abstract | OBJECTIVE: To identify a polyunsaturated fatty acid (PUFA) biomarker able to detect which women with singleton pregnancies are most likely to benefit from omega-3 supplementation to reduce their risk of early preterm birth. DESIGN: Exploratory analysis of a randomised controlled trial. SETTING: Six Australian hospitals. POPULATION: Women with a singleton pregnancy enrolled in the ORIP trial. METHODS: Using maternal capillary whole blood collected ~14 weeks' gestation, the fatty acids in total blood lipids were quantified using gas chromatography. Interaction tests examined whether baseline PUFA status modified the effect of omega-3 supplementation on birth outcomes. MAIN OUTCOME MEASURE: Early preterm birth (<34 weeks' gestation). RESULTS: A low total omega-3 PUFA status in early pregnancy was associated with a higher risk of early preterm birth. Among women with a total omega-3 status ≤4.1% of total fatty acids, omega-3 supplementation substantially reduced the risk of early preterm birth compared with control (0.73% vs. 3.16%; relative risk=0.23, 95% CI 0.07-0.79). Conversely, women with higher total omega-3 status in early pregnancy were at lower risk of early preterm birth. Supplementing women with a baseline status above 4.9% increased early preterm birth (2.20% vs. 0.97%; relative risk=2.27, 95% CI 1.13-4.58). CONCLUSIONS: Women with singleton pregnancies and low total omega-3 PUFA status early in pregnancy have an increased risk of early preterm birth and are most likely to benefit from omega-3 supplementation to reduce this risk. Women with higher total omega-3 status are at lower risk and additional omega-3 supplementation may increase their risk. | - |
dc.description.statementofresponsibility | LA Simmonds, TR Sullivan, M Skubisz, PF Middleton, KP Best ... et al. | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.rights | © 2020 Royal College of Obstetricians and Gynaecologists | - |
dc.source.uri | http://dx.doi.org/10.1111/1471-0528.16168 | - |
dc.subject | Omega-3 fatty acids | - |
dc.subject | biomarker | - |
dc.subject | docosahexaenoic acid | - |
dc.subject | preterm birth | - |
dc.title | Omega-3 fatty acid supplementation in pregnancy - baseline omega-3 status and early preterm birth: exploratory analysis of a randomised controlled trial | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/1471-0528.16168 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1050468 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1052388 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1046207 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1061704 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Simmonds, L.A. [0000-0002-4795-5141] | - |
dc.identifier.orcid | Middleton, P.F. [0000-0002-8573-338X] | - |
dc.identifier.orcid | Best, K.P. [0000-0002-7653-5074] | - |
dc.identifier.orcid | Yelland, L.N. [0000-0003-3803-8728] | - |
dc.identifier.orcid | Zhou, S.J. [0000-0003-4012-983X] | - |
dc.identifier.orcid | McPhee, A.J. [0000-0003-3820-5696] | - |
dc.identifier.orcid | Gibson, R.A. [0000-0002-8750-525X] | - |
dc.identifier.orcid | Makrides, M. [0000-0003-3832-541X] | - |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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