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Type: Journal article
Title: Immune cells at the fetomaternal interface: how the microenvironment modulates immune cells to foster fetal development
Author: Schumacher, A.
Sharkey, D.
Robertson, S.
Zenclussen, A.
Citation: Journal of Immunology, 2018; 201(2):325-334
Publisher: American Association of Immunologists
Issue Date: 2018
ISSN: 0022-1767
Statement of
Anne Schumacher, David J. Sharkey, Sarah A. Robertson, and Ana C. Zenclussen
Abstract: Immune cells adapt their phenotypic and functional characteristics in response to the tissue microenvironment within which they traffic and reside. The fetomaternal interface, consisting of placental trophoblasts and the maternal decidua, is a highly specialized tissue with a unique and time-limited function: to nourish and support development of the semiallogeneic fetus and protect it from inflammatory or immune-mediated injury. It is therefore important to understand how immune cells within these tissues are educated and adapt to fulfill their biological functions. This review article focuses on the local regulatory mechanisms ensuring that both innate and adaptive immune cells appropriately support the early events of implantation and placental development through direct involvement in promoting immune tolerance of fetal alloantigens, suppressing inflammation, and remodeling of maternal uterine vessels to facilitate optimal placental function and fetal growth.
Keywords: Fetus
Rights: Copyright © 2018 by The American Association of Immunologists, Inc.
DOI: 10.4049/jimmunol.1800058
Appears in Collections:Aurora harvest 3
Obstetrics and Gynaecology publications

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