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https://hdl.handle.net/2440/124626
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Type: | Journal article |
Title: | Social and economic factors, maternal behaviours in pregnancy and neonatal adiposity in the PANDORA cohort |
Author: | Longmore, D.K. Laurel Mary Barr, E. Barzi, F. Lee, I.-L. Kirkwood, M. Connors, C. Boyle, J. O'Dea, K. Zimmet, P. Oats, J. Catalano, P. David Mcintyre, H. Brown, A.D.H. Shaw, J.E. Maple-Brown, L.J. PANDORA study research team, |
Citation: | Diabetes Research and Clinical Practice, 2020; 161:108028-1-108028-11 |
Publisher: | Elsevier |
Issue Date: | 2020 |
ISSN: | 0168-8227 1872-8227 |
Statement of Responsibility: | Danielle K. Longmore, Elizabeth L.M. Barr, Federica Barzi, I-Lynn Lee, Marie Kirkwood, Christine Connors, Jacqueline Boyle, Kerin O’Dea, Paul Zimmet, Jeremy Oats, Patrick Catalano, H. David McIntyre, Alex D.H. Brown, Jonathan E. Shaw, Louise J. Maple-Brown, on behalf of the PANDORA study research team |
Abstract: | Background: Australian Indigenous women experience high rates of social disadvantage and type 2 diabetes (T2D) in pregnancy, but it is not known how social factors and maternal behaviours impact neonatal adiposity in offspring of women with hyperglycaemia in pregnancy. Methods: Participants were Indigenous (n=404) and Europid (n=240) women with gestational diabetes mellitus (GDM) or T2D in pregnancy and their offspring in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study. Social, economic factors, and maternal behaviours were measured in pregnancy and six neonatal anthropometric outcomes were examined after birth. Results: On univariate analysis, maternal education <12 years (p=0.03), unemployment (p=0.001), welfare income vs no welfare income (p=0.001), lower area based socio-economic score (p<0.001), and fast food intake >2 times/week (p=0.002) were associated with increased sum of skinfolds (SSF) in offspring. Smoking was significantly associated with a reduction in anthropometric measures, except SSF. In multivariable models adjusted for ethnicity, BMI and hyperglycaemia, social and economic factors were no longer significant predictors of neonatal outcomes. Smoking was independently associated with a reduction in length, head circumference and fat free mass. Frequent fast food intake remained independently associated with SSF (β-coefficient 1.08mm, p=0.02). Conclusion: In women with hyperglycaemia in pregnancy, social factors were associated with neonatal adiposity, particularly skinfold measures. Promoting smoking cessation and limited intake of energy-dense, nutrient-poor foods in pregnancy are important to improve neonatal adiposity and lean mass outcomes. Addressing inequities in social and economic factors are likely to be important, particularly for Indigenous women or women experiencing social disadvantage. |
Keywords: | Diabetes; indigenous; hyperglycaemia in pregnancy; neonatal adiposity; socio-economic |
Rights: | © 2020 Elsevier B.V. All rights reserved. |
DOI: | 10.1016/j.diabres.2020.108028 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1032116 http://purl.org/au-research/grants/nhmrc/1078333 http://purl.org/au-research/grants/nhmrc/1038372 http://purl.org/au-research/grants/nhmrc/605837 http://purl.org/au-research/grants/nhmrc/1078477 http://purl.org/au-research/grants/nhmrc/1137563 http://purl.org/au-research/grants/nhmrc/1079438 |
Published version: | http://dx.doi.org/10.1016/j.diabres.2020.108028 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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