Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/124678
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dc.contributor.author | Gan, L. | - |
dc.contributor.author | Sun, J. | - |
dc.contributor.author | Yang, S. | - |
dc.contributor.author | Zhang, X. | - |
dc.contributor.author | Chen, W. | - |
dc.contributor.author | Sun, Y. | - |
dc.contributor.author | Wu, X. | - |
dc.contributor.author | Cheng, C. | - |
dc.contributor.author | Yuan, J. | - |
dc.contributor.author | Li, A. | - |
dc.contributor.author | Corbett, M.A. | - |
dc.contributor.author | Dixon, M.P. | - |
dc.contributor.author | Thomas, T. | - |
dc.contributor.author | Voss, A.K. | - |
dc.contributor.author | Gécz, J. | - |
dc.contributor.author | Wang, G.-Z. | - |
dc.contributor.author | Bonni, A. | - |
dc.contributor.author | Li, Q. | - |
dc.contributor.author | Huang, J. | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Cell Reports, 2020; 30(11):3717-3728.e6 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | http://hdl.handle.net/2440/124678 | - |
dc.description.abstract | Understanding the mechanisms of activity-dependent gene transcription underlying adaptive behaviors is challenging at neuronal-subtype resolution. Using cell-type specific molecular analysis in agouti-related peptide (AgRP) neurons, we reveal that the profound hunger-induced transcriptional changes greatly depend on plant homeodomain finger protein 6 (PHF6), a transcriptional repressor enriched in AgRP neurons. Loss of PHF6 in the satiated mice results in a hunger-state-shifting transcriptional profile, while hunger fails to further induce a rapid and robust activity-dependent gene transcription in PHF6-deficient AgRP neurons. We reveal that PHF6 binds to the promoters of a subset of immediate-early genes (IEGs) and that this chromatin binding is dynamically regulated by hunger state. Depletion of PHF6 decreases hunger-driven feeding motivation and makes the mice resistant to body weight gain under repetitive fasting-refeeding conditions. Our work identifies a neuronal subtype-specific transcriptional repressor that modulates transcriptional profiles in different nutritional states and enables adaptive eating behavior. | - |
dc.description.statementofresponsibility | Linhua Gan, Jingjing Sun, Shuo Yang, Xiaocui Zhang ... Mark A. Corbett ... Jozef Gécz ... et al. | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | © 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | - |
dc.source.uri | http://dx.doi.org/10.1016/j.celrep.2020.02.085 | - |
dc.subject | AgRP neuron | - |
dc.subject | BFLS | - |
dc.subject | Börjeson-Forssman-Lehmann syndrome | - |
dc.subject | IEGs | - |
dc.subject | PHF6 | - |
dc.subject | activity-dependent gene transcription | - |
dc.subject | hunger-driven feeding behavior | - |
dc.subject | immediate-early genes | - |
dc.title | Chromatin-binding protein PHF6 regulates activity-dependent transcriptional networks to promote hunger response | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.celrep.2020.02.085 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1029481 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1084248 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1003435 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1155224 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/575512 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1081421 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Corbett, M.A. [0000-0001-9298-3072] | - |
dc.identifier.orcid | Gécz, J. [0000-0002-7884-6861] | - |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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hdl_124678.pdf | Published version | 5.68 MB | Adobe PDF | View/Open |
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