1. Adelaide Research & Scholarship
  2. Schools and Disciplines
  3. School of Medicine
  4. Medicine
  5. Medicine publications
Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/124995
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorYeoh, Y.Q.-
dc.contributor.authorHorsley, J.R.-
dc.contributor.authorPolyak, S.W.-
dc.contributor.authorAbell, A.D.-
dc.date.issued2020-
dc.identifier.citationBioorganic and Medicinal Chemistry Letters, 2020; 30(11):127140-1-127140-3-
dc.identifier.issn0960-894X-
dc.identifier.issn1464-3405-
dc.identifier.urihttp://hdl.handle.net/2440/124995-
dc.description.abstractA prodrug based on a known antibacterial compound is reported to target Staphylococcus aureus and Escherichia coli under reductive conditions. The prodrug was prepared by masking the N-terminus and side chain amines of a component lysine residue as 4-nitrobenzyl carbamates. Activation to liberate the antibacterial was demonstrated on treatment with a model reductant, tin(II) chloride. The bioactivity of 1 was confirmed in antibacterial susceptibility assays whereas prodrug 2 was inactive.-
dc.description.statementofresponsibilityYuan Qi Yeoh, John R. Horsley, Steven W. Polyak, Andrew D. Abell-
dc.language.isoen-
dc.publisherElsevier-
dc.rights© 2020 Elsevier Ltd. All rights reserved.-
dc.source.urihttp://dx.doi.org/10.1016/j.bmcl.2020.127140-
dc.subjectAntibacterial-
dc.subjectE. coli-
dc.subjectHypoxia-activated-
dc.subjectProdrug-
dc.subjectS. aureus-
dc.titleA hypoxia-activated antibacterial prodrug-
dc.typeJournal article-
dc.identifier.doi10.1016/j.bmcl.2020.127140-
dc.relation.granthttp://purl.org/au-research/grants/arc/CE140100003-
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/GNT1147538-
pubs.publication-statusPublished-
dc.identifier.orcidYeoh, Y.Q. [0000-0002-0052-4213]-
dc.identifier.orcidPolyak, S.W. [0000-0002-8458-5194]-
dc.identifier.orcidAbell, A.D. [0000-0002-0604-2629]-
Appears in Collections:Aurora harvest 8
Medicine publications

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.