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https://hdl.handle.net/2440/125205
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Type: | Journal article |
Title: | Evaluation of implementation of risk management guidelines for carriers of pathogenic variants in mismatch repair genes: a nationwide audit of familial cancer clinics |
Author: | Meiser, B. Kaur, R. Kirk, J. Morrow, A. Peate, M. Wong, W.K.T. McPike, E. Cops, E. Dowson, C. Austin, R. Fine, M. Thrupp, L. Ward, R. Macrae, F. Hiller, J.E. Trainer, A.H. Mitchell, G. Susman, R. Pachter, N. Goodwin, A. et al. |
Citation: | Familial Cancer, 2020; 19(4):337-346 |
Publisher: | Springer |
Issue Date: | 2020 |
ISSN: | 1389-9600 1573-7292 |
Statement of Responsibility: | B. Meiser, R. Kaur, J. Kirk, A. Morrow ... Janet Hiller ... Nicola Poplawski ... et al. |
Abstract: | Introduction: This nationwide study assessed the impact of Lynch syndrome-related risk management guidelines on clinicians’ recommendations of risk management strategies to carriers of pathogenic variants in mismatch repair genes and the extent to which carriers took up strategies in concordance with guidelines. Materials and methods: Clinic files of 464 carriers (with and without colorectal cancer) were audited for carriers who received their genetic testing results in July 2008–July 2009 (i.e. before guideline release), July 2010–July 2011 and July 2012–July 2013 (both after guideline release) at 12 familial cancer clinics (FCCs) to ascertain the extent to which carriers were informed about risk management in accordance with guidelines. All carriers captured by the audit were invited to participate in interviews; 215 were interviewed to assess adherence to recommended risk management guidelines. Results: The rates of documentation in clinic files increased significantly from pre- to post-guideline for only two out of eight risk management strategies. The strategies with the highest compliance of carriers post-guidelines were: uptake of one or two-yearly colonoscopy (87%), followed by hysterectomy to prevent endometrial cancer (68%), aspirin as risk-reducing medication (67%) and risk-reducing salpingo-oophorectomy (63%). Interrater reliability check for all guidelines showed excellent agreement (k statistics = 0.89). Conclusion: These results indicate that there is scope to further increase provision of advice at FCCs to ensure that all carriers receive recommendations about evidence-based risk management. A multi-pronged behaviour change and implementation science approach tailored to specific barriers is likely to be needed to achieve optimal clinician behaviours and outcomes for carriers. |
Keywords: | ICCon Audit Study Collaborative Group Humans Colorectal Neoplasms Colorectal Neoplasms, Hereditary Nonpolyposis Stomach Neoplasms Ovarian Neoplasms Endometrial Neoplasms Aspirin Anticarcinogenic Agents Colonoscopy Gastroscopy Hysterectomy Risk Assessment Reproducibility of Results Patient Compliance Heterozygote Adult Middle Aged Guideline Adherence Medical Audit Female Male DNA Mismatch Repair Genetic Testing Salpingo-oophorectomy |
Description: | Published: 09 May 2020 |
Rights: | © Springer Nature B.V. 2020 |
DOI: | 10.1007/s10689-020-00183-4 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1078523 |
Published version: | http://dx.doi.org/10.1007/s10689-020-00183-4 |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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