Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/128504
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Type: | Journal article |
Title: | Daily access to sucrose impairs aspects of spatial memory tasks reliant on pattern separation and neural proliferation in rats |
Author: | Reichelt, A.C. Morris, M.J. Westbrook, R.F. |
Citation: | Learning and Memory, 2016; 23(7):386-390 |
Publisher: | Cold Spring Harbor Laboratory Press |
Issue Date: | 2016 |
ISSN: | 1072-0502 1549-5485 |
Statement of Responsibility: | Amy C. Reichelt, Margaret J. Morris and Reginald Frederick Westbrook |
Abstract: | High sugar diets reduce hippocampal neurogenesis, which is required for minimizing interference between memories, a process that involves "pattern separation." We provided rats with 2 h daily access to a sucrose solution for 28 d and assessed their performance on a spatial memory task. Sucrose consuming rats discriminated between objects in novel and familiar locations when there was a large spatial separation between the objects, but not when the separation was smaller. Neuroproliferation markers in the dentate gyrus of the sucrose-consuming rats were reduced relative to controls. Thus, sucrose consumption impaired aspects of spatial memory and reduced hippocampal neuroproliferation. |
Keywords: | Dentate Gyrus |
Rights: | © 2016 Reichelt et al.; Published by Cold Spring Harbor Laboratory Press This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
DOI: | 10.1101/lm.042416.116 |
Grant ID: | http://purl.org/au-research/grants/arc/DE140101071 |
Published version: | http://dx.doi.org/10.1101/lm.042416.116 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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hdl_128504.pdf | Published version | 547.22 kB | Adobe PDF | View/Open |
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