Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/128504
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Type: Journal article
Title: Daily access to sucrose impairs aspects of spatial memory tasks reliant on pattern separation and neural proliferation in rats
Author: Reichelt, A.
Morris, M.
Westbrook, R.
Citation: Learning and Memory, 2016; 23(7):386-390
Publisher: Cold Spring Harbor Laboratory Press
Issue Date: 2016
ISSN: 1072-0502
1549-5485
Statement of
Responsibility: 
Amy C. Reichelt, Margaret J. Morris and Reginald Frederick Westbrook
Abstract: High sugar diets reduce hippocampal neurogenesis, which is required for minimizing interference between memories, a process that involves "pattern separation." We provided rats with 2 h daily access to a sucrose solution for 28 d and assessed their performance on a spatial memory task. Sucrose consuming rats discriminated between objects in novel and familiar locations when there was a large spatial separation between the objects, but not when the separation was smaller. Neuroproliferation markers in the dentate gyrus of the sucrose-consuming rats were reduced relative to controls. Thus, sucrose consumption impaired aspects of spatial memory and reduced hippocampal neuroproliferation.
Keywords: Dentate Gyrus
Rights: © 2016 Reichelt et al.; Published by Cold Spring Harbor Laboratory Press This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
RMID: 1000025750
DOI: 10.1101/lm.042416.116
Grant ID: http://purl.org/au-research/grants/arc/DE140101071
Appears in Collections:Medicine publications

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