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Type: Journal article
Title: Should we look for a low-grade threshold for blastocyst transfer? A scoping review
Author: Kemper, J.M.
Liu, Y.
Afnan, M.
Hammond, E.R.
Morbeck, D.E.
Mol, B.W.J.
Citation: Reproductive Biomedicine Online, 2021; 42(4):709-716
Publisher: Elsevier
Issue Date: 2021
ISSN: 1472-6483
Statement of
James M.Kemper, Yanhe Liu, Masoud Afnan, Elizabeth R.Hammond, Dean E.Morbeck, Ben W.J.Mol
Abstract: Embryo quality is a key determinant of the success of IVF. Although the focus has been on selecting the best embryo for transfer, the classification of low-grade blastocysts (LGB) in existing scoring systems has received less attention. This is worrisome; embryo freezing allows optimal use of all created embryos, thus maximizing the cumulative live birth rate, which is arguably the most important outcome for infertile couples. A PubMed search was conducted in August 2020, using ‘(((‘poor-quality’ OR ‘poor quality’) OR (‘low-grade’ OR ‘low grade’)) AND (‘embryo’ OR ‘blastocyst’)) AND (‘pregnancy’ OR ‘live birth’)’. This scoping review shows that LGB have similar euploidy and pregnancy success rates after implantation and have no adverse effects on pregnancy or perinatal outcomes. Evidence for pregnancy outcomes is lacking for different grades of LGB, with most studies clustering all LQB as one to compare with optimal blastocysts.
Keywords: Blastocyst; embryo transfer; low-grade; quality; threshold
Rights: © 2021 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.rbmo.2021.01.019
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Obstetrics and Gynaecology publications

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