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dc.contributor.authorPhyo, A.Z.Z.-
dc.contributor.authorGonzalez-Chica, D.A.-
dc.contributor.authorStocks, N.P.-
dc.contributor.authorStorey, E.-
dc.contributor.authorWoods, R.L.-
dc.contributor.authorMurray, A.M.-
dc.contributor.authorOrchard, S.G.-
dc.contributor.authorShah, R.C.-
dc.contributor.authorGasevic, D.-
dc.contributor.authorFreak-Poli, R.-
dc.contributor.authorRyan, J.-
dc.contributor.authorASPREE Investigator Group-
dc.identifier.citationJournal of Alzheimer's Disease, 2021; 80(2):895-904-
dc.description.abstractBACKGROUND: Health-related quality of life (HRQoL) has been shown to predict adverse health outcome in the general population. OBJECTIVE: We examined the cross-sectional association between HRQoL and cognitive performance at baseline. Next, we explored whether baseline HRQoL predicted 5-year incident cognitive decline and dementia and whether there were gender differences. METHODS: 19,106 community-dwelling participants from the ASPirin in Reducing Events in the Elderly (ASPREE) trial, aged 65-98 years, free of major cognitive impairments, and completed the HRQoL 12-item short-form (SF-12) at baseline (2010-2014), were followed until June 2017. The physical (PCS) and mental component scores (MCS) of SF-12 were calculated. The cognitive tests were assessed at baseline, year 1, 3, 5, and 7 or close-out visit. Cognitive decline was defined as > 1.5 SD drop from baseline on any of the cognitive tests. Dementia was adjudicated according to DSM-IV criteria. Linear and Cox proportional-hazards regressions were used to examine the cross-sectional and longitudinal associations respectively. RESULTS: At baseline, higher PCS and MCS were associated with better cognition. Over a median 4.7-year follow-up, higher MCS was associated with a reduced risk of cognitive decline and dementia (12% and 15% respectively, per 10-unit increase) and a 10-unit higher PCS was associated with a 6% decreased risk of cognitive decline. PCS did not predict dementia incidence. Findings were not different by gender. CONCLUSION: Our study found that higher HRQoL, in particular MCS, predicted a reduced risk of cognitive decline and dementia over time in community-dwelling older people.-
dc.description.statementofresponsibilityAung Zaw Zawa Phyo, David A. Gonzalez-Chica, Nigel P. Stocks, Elsdona Storey, Robyn L. Woods, Anne M. Murray … et al.-
dc.publisherIOS Press-
dc.rights© 2021 – IOS Press. All rights reserved.-
dc.subjectcognitive dysfunction-
dc.subjecthealth-related quality of life (HRQoL)-
dc.subjectquality of life-
dc.titleThe utility of assessing health-related quality of life to predict cognitive decline and dementia-
dc.typeJournal article-
dc.identifier.orcidGonzalez-Chica, D.A. [0000-0002-7153-2878]-
dc.identifier.orcidStocks, N.P. [0000-0002-9018-0361]-
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