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https://hdl.handle.net/2440/130936
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dc.contributor.author | Phyo, A.Z.Z. | - |
dc.contributor.author | Gonzalez-Chica, D.A. | - |
dc.contributor.author | Stocks, N.P. | - |
dc.contributor.author | Storey, E. | - |
dc.contributor.author | Woods, R.L. | - |
dc.contributor.author | Murray, A.M. | - |
dc.contributor.author | Orchard, S.G. | - |
dc.contributor.author | Shah, R.C. | - |
dc.contributor.author | Gasevic, D. | - |
dc.contributor.author | Freak-Poli, R. | - |
dc.contributor.author | Ryan, J. | - |
dc.contributor.author | ASPREE Investigator Group, | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Journal of Alzheimer's Disease, 2021; 80(2):895-904 | - |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.issn | 1875-8908 | - |
dc.identifier.uri | http://hdl.handle.net/2440/130936 | - |
dc.description.abstract | BACKGROUND: Health-related quality of life (HRQoL) has been shown to predict adverse health outcome in the general population. OBJECTIVE: We examined the cross-sectional association between HRQoL and cognitive performance at baseline. Next, we explored whether baseline HRQoL predicted 5-year incident cognitive decline and dementia and whether there were gender differences. METHODS: 19,106 community-dwelling participants from the ASPirin in Reducing Events in the Elderly (ASPREE) trial, aged 65-98 years, free of major cognitive impairments, and completed the HRQoL 12-item short-form (SF-12) at baseline (2010-2014), were followed until June 2017. The physical (PCS) and mental component scores (MCS) of SF-12 were calculated. The cognitive tests were assessed at baseline, year 1, 3, 5, and 7 or close-out visit. Cognitive decline was defined as > 1.5 SD drop from baseline on any of the cognitive tests. Dementia was adjudicated according to DSM-IV criteria. Linear and Cox proportional-hazards regressions were used to examine the cross-sectional and longitudinal associations respectively. RESULTS: At baseline, higher PCS and MCS were associated with better cognition. Over a median 4.7-year follow-up, higher MCS was associated with a reduced risk of cognitive decline and dementia (12% and 15% respectively, per 10-unit increase) and a 10-unit higher PCS was associated with a 6% decreased risk of cognitive decline. PCS did not predict dementia incidence. Findings were not different by gender. CONCLUSION: Our study found that higher HRQoL, in particular MCS, predicted a reduced risk of cognitive decline and dementia over time in community-dwelling older people. | - |
dc.description.statementofresponsibility | Aung Zaw Zawa Phyo, David A. Gonzalez-Chica, Nigel P. Stocks, Elsdona Storey, Robyn L. Woods, Anne M. Murray … et al. | - |
dc.language.iso | en | - |
dc.publisher | IOS Press | - |
dc.rights | © 2021 – IOS Press. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.3233/jad-201349 | - |
dc.subject | Cognition | - |
dc.subject | cognitive dysfunction | - |
dc.subject | dementia | - |
dc.subject | health-related quality of life (HRQoL) | - |
dc.subject | quality of life | - |
dc.title | The utility of assessing health-related quality of life to predict cognitive decline and dementia | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.3233/JAD-201349 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Gonzalez-Chica, D.A. [0000-0002-7153-2878] | - |
dc.identifier.orcid | Stocks, N.P. [0000-0002-9018-0361] | - |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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