Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/131092
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Type: Journal article
Title: Prescribing and deprescribing in chronic kidney disease
Author: Manski-Nankervis, J.-.A.
McMorrow, R.
Nelson, C.
Jesudason, S.
Sluggett, J.K.
Citation: Australian Journal of General Practice, 2021; 50(4):183-187
Publisher: Royal Australian College of General Practitioners
Issue Date: 2021
ISSN: 2208-794X
2208-7958
Statement of
Responsibility: 
Jo-Anne Manski-Nankervis, Rita McMorrow, Craig Nelson, Shilpanjali Jesudason, Janet K Sluggett
Abstract: Background: Chronic kidney disease (CKD) rarely occurs in isolation; multimorbidity is the norm. As a result, polypharmacy is common in people with CKD. Some medications are indicated to reduce the risk of cardiovascular disease and progression of CKD. In contrast, some medications may require dose reduction or cessation as a result of advancing stages of CKD. Objective: The aim of this article is to describe broad principles of managing the challenges and necessities of polypharmacy in patients with CKD. Discussion: Medications such as angiotensin converting enzyme inhibitors, angiotensin receptor blockers, statins and sodium-glucose co-transporter-2 inhibitors may reduce cardiovascular disease risk and/or reduce CKD progression, and their use should be balanced by likelihood of benefit. Medication cessation or dose reduction may be required to prevent medication accumulation, adverse medication events and kidney injury. Polypharmacy can be addressed with a collaborative Home Medicines Review and use of deprescribing tools, using a shared decision-making approach.
Rights: © The Royal Australian College of General Practitioners 2021
RMID: 1000039818
DOI: 10.31128/ajgp-11-20-5752
Grant ID: http://purl.org/au-research/grants/nhmrc/1168265
http://purl.org/au-research/grants/nhmrc/1156439
Appears in Collections:Medicine publications

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