Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/131429
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Type: Journal article
Title: Effect of Testosterone treatment on bone microarchitecture and bone mineral density in men: a two-year RCT
Author: Ng Tang Fui, M.
Hoermann, R.
Bracken, K.
Handelsman, D.J.
Inder, W.J.
Stuckey, B.G.A.
Yeap, B.B.
Ghasem-Zadeh, A.
McLachlan, R.
Robledo, K.P.
Jesudason, D.
Zajac, J.D.
Wittert, G.A.
Grossmann, M.
Citation: Journal of Clinical Endocrinology and Metabolism, 2021; 106(8):e3143-e3158
Publisher: Oxford University Press
Issue Date: 2021
ISSN: 0021-972X
1945-7197
Statement of
Responsibility: 
Mark Ng Tang Fui, Rudolf Hoermann, Karen Bracken, David J Handelsman, Warrick J Inder, Bronwyn G A Stuckey ... et al.
Abstract: CONTEXT: Testosterone treatment increases bone mineral density (BMD) in hypogonadal men. Effects on bone microarchitecture, a determinant of fracture risk, are unknown. OBJECTIVE: Determine the effect of testosterone treatment on bone microarchitecture using high resolution-peripheral quantitative computed tomography (HR-pQCT). DESIGN, SETTING, PARTICIPANTS: Men>50 years were recruited from six Australian centres. INTERVENTIONS: Injectable testosterone undecanoate or placebo over 2 years on the background of a community-based lifestyle program. MAIN OUTCOMES: Primary endpoint was cortical volumetric BMD (vBMD) at the distal tibia, measured using HR-pQCT in 177 men (one centre). Secondary endpoints included other HR-pQCT parameters and bone remodelling markers. Areal BMD (aBMD) was measured by dual energy X-ray absorptiometry (DXA) in 601 men (five centres). Using a linear mixed model for repeated measures, the mean adjusted differences (MAD) [95% CI] at 12 and 24 months between groups are reported as treatment effect. RESULTS: Over 24 months, testosterone treatment, compared to placebo, increased tibial cortical vBMD), 9.33mgHA/cm 3[3.96;14.71],p<0.001 or 3.1%[1.2;5.0], radial cortical vBMD, 8.96mgHA/cm 3[3.30;14.62],p=0.005 or 2.9%[1.0;4.9], total tibial vBMD, 4.16mgHA/cm 3[2.14;6.19],p<0.001 or 1.3%[0.6;1.9] and total radial vBMD, 4.42mgHA/cm 3[1.67;7.16],p=0.002 or 1.8%[0.4;2.0]. Testosterone also significantly increased cortical area and thickness at both sites. Effects on trabecular architecture were minor. Testosterone reduced bone remodeling markers CTX, -48.1ng/L[-81.1;-15.1],p<0.001, and P1NP, -6.8μg/L[-10.9;-2.7], p<0.001. Testosterone significantly increased aBMD at the lumbar spine, 0.04 g/cm 2[0.03;0.05],p<0.001, and the total hip, 0.01g/cm 2[0.01;0.02],p<0.001. CONCLUSIONS: In men>50 years, testosterone treatment for 2 years increased volumetric bone density, predominantly via effects on cortical bone. Implications for fracture risk reduction require further study.
Keywords: T4DM
bone
microarchitecture
testosterone
Rights: © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved.
DOI: 10.1210/clinem/dgab149
Grant ID: http://purl.org/au-research/grants/nhmrc/1030123
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