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Type: Journal article
Title: Perspectives on the development and future of oocyte IVM in clinical practice
Author: De Vos, M.
Grynberg, M.
Ho, T.M.
Yuan, Y.
Albertini, D.F.
Gilchrist, R.B.
Citation: Journal of Assisted Reproduction and Genetics, 2021; 38(6):1265-1280
Publisher: Springer
Issue Date: 2021
ISSN: 1058-0468
Statement of
Michel De Vos, Michaël Grynberg, Tuong M. Ho, Ye Yuan, David F. Albertini, Robert B. Gilchrist
Abstract: Oocyte in vitro maturation (IVM) is an assisted reproductive technology designed to obtain mature oocytes following culture of immature cumulus-oocyte complexes collected from antral follicles. Although IVM has been practiced for decades and is no longer considered experimental, the uptake of IVM in clinical practice is currently limited. The purpose of this review is to ensure reproductive medicine professionals understand the appropriate use of IVM drawn from the best available evidence supporting its clinical potential and safety in selected patient groups. This group of scientists and fertility specialists, with expertise in IVM in the ART laboratory and/or clinic, explore here the development of IVM towards acquisition of a non-experimental status and, in addition, critically appraise the current and future role of IVM in human ART.
Keywords: Fertility preservation
In vitro maturation (IVM)
Oocyte maturation
Polycystic ovary syndrome (PCOS)
Rights: © Crown 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adap tation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, pro vide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit
DOI: 10.1007/s10815-021-02263-5
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