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Type: Journal article
Title: Roles of microRNAs in osteogenesis or adipogenesis differentiation of bone marrow stromal progenitor cells
Author: Zhang, Y.-L.
Liu, L.
Peymanfar, Y.
Anderson, P.
Xian, C.J.
Citation: International Journal of Molecular Sciences, 2021; 22(13)
Publisher: MDPI AG
Issue Date: 2021
ISSN: 1422-0067
Statement of
Ya-Li Zhang, Liang Liu, Yaser Peymanfar, Paul Anderson and Cory J. Xian
Abstract: Bone marrow stromal cells (BMSCs) are multipotent cells which can differentiate into chondrocytes, osteoblasts, and fat cells. Under pathological stress, reduced bone formation in favour of fat formation in the bone marrow has been observed through a switch in the differentiation of BMSCs. The bone/fat switch causes bone growth defects and disordered bone metabolism in bone marrow, for which the mechanisms remain unclear, and treatments are lacking. Studies suggest that small non-coding RNAs (microRNAs) could participate in regulating BMSC differentiation by disrupting the post-transcription of target genes, leading to bone/fat formation changes. This review presents an emerging concept of microRNA regulation in the bone/fat formation switch in bone marrow, the evidence for which is assembled mainly from in vivo and in vitro human or animal models. Characterization of changes to microRNAs reveals novel networks that mediate signalling and factors in regulating bone/fat switch and homeostasis. Recent advances in our understanding of microRNAs in their control in BMSC differentiation have provided valuable insights into underlying mechanisms and may have significant potential in development of new therapeutics.
Keywords: BMSC differentiation; bone/fat formation; microRNAs
Rights: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
DOI: 10.3390/ijms22137210
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