Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/131840
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Type: Journal article
Title: Identifying subgroups of community-dwelling older adults and their prospective associations with long-term knee osteoarthritis outcomes
Author: Munugoda, I.P.
Pan, F.
Wills, K.
Mattap, S.M.
Cicuttini, F.
Graves, S.E.
Lorimer, M.
Jones, G.
Callisaya, M.L.
Aitken, D.
Citation: Clinical Rheumatology, 2020; 39(5):1429-1437
Publisher: Springer Science and Business Media
Issue Date: 2020
ISSN: 0770-3198
1434-9949
Statement of
Responsibility: 
Ishanka P. Munugoda, Feng Pan, Karen Wills, Siti M. Mattap, Flavia Cicuttini, Stephen E. Graves ... et al.
Abstract: Objectives: To identify subgroups of community-dwelling older adults and to assess their longitudinal associations with long-term osteoarthritis (OA) outcomes. Methods: 1046 older adults aged 50–80 years were studied. At baseline, body mass index (BMI), pedometer-measured ambulatory activity (AA), and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) determined knee pain and information on comorbidities were obtained. Tibial cartilage volume and bone-marrow lesions (BMLs) were assessed using MRI at baseline and 10 years and total knee replacements (TKR) by data linkage to the Australian Orthopaedic Association National Joint Replacement Registry. Latent class analysis was used to determine participant subgroups, considering baseline BMI, AA, pain and comorbidities, and linear mixed-effects or log-binomial models were used to assess the associations. Results: Three subgroups/classes were identified: subgroup 1 (43%): Normal/overweight participants with higher AA, lower pain and lower comorbidities; subgroup 2 (32%): Overweight participants with lower AA, mild pain and higher comorbidities; subgroup 3 (25%): Obese participants with lower AA, mild pain and higher comorbidities. Subgroup 3 had greater cartilage volume loss (β − 60.56 mm3, 95% CI − 105.91, − 15.21) and a higher risk of TKR (RR 3.19, 95% CI 1.75, 5.81), compared to subgroup 1. Subgroup 2 was not associated with cartilage volume change (β 13.06 mm3, 95% CI − 30.87, 57.00) or risk of TKR (RR 1.16, 95% CI 0.56, 2.36), compared to subgroup 1. Subgroup membership was not associated with worsening BMLs. Conclusions: Our findings suggest the existence of homogeneous subgroups of participants and support the utility of identifying patterns of characteristics/risk factors that may cluster together and using them to identify subgroups of people who may be at a higher risk of developing and/or progressing OA.
Keywords: Knee
Rights: © 2020, International League of Associations for Rheumatology (ILAR)
DOI: 10.1007/s10067-019-04920-8
Grant ID: http://purl.org/au-research/grants/nhmrc/302204
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