Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/131857
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Type: Journal article
Title: The influence of DHA supplementation during pregnancy on language development across childhood: follow-up of a randomised controlled trial
Author: Gawlik, N.R.
Makrides, M.
Kettler, L.
Yelland, L.N.
Leemaqz, S.
Gould, J.F.
Citation: Prostaglandins, Leukotrienes and Essential Fatty Acids, 2020; 163:102207-1-102207-12
Publisher: Elsevier
Issue Date: 2020
ISSN: 0952-3278
1532-2823
Statement of
Responsibility: 
N.R. Gawlik, M. Makrides, L. Kettler, L.N. Yelland, S. Leemaqz, J.F. Gould
Abstract: Numerous randomised controlled trials have explored the effect of docosahexaenoic acid (DHA) supplementation in early life on neurodevelopment, with some suggested positive effects on language. Australian women with a singleton pregnancy <21 weeks' gestation were randomised to receive 800 mg DHA/day or a placebo until birth. A sample of 726 children (all n=96 born preterm, random sample of n=630 born at term) were invited to undergo assessments of language, academic, and language-based cognitive abilities at 1.5, four and seven years of age. No group differences were detected for any group comparison. Exploratory analyses for sex by treatment interactions revealed a possible adverse effect of DHA supplementation on the language of females at 1.5 years but no effects on outcomes at four or seven years. Taken as a whole, evidence of an effect of prenatal DHA supplementation on language abilities across childhood is negligible and could be a chance finding.
Keywords: DHA; omega-3 fatty acids; pregnancy; supplementation; language; verbal abilities
Rights: © 2020 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.plefa.2020.102207
Grant ID: http://purl.org/au-research/grants/nhmrc/1061704
http://purl.org/au-research/grants/nhmrc/1052388
http://purl.org/au-research/grants/nhmrc/349301
http://purl.org/au-research/grants/nhmrc/627174
http://purl.org/au-research/grants/nhmrc/1048493
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