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https://hdl.handle.net/2440/131857
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Type: | Journal article |
Title: | The influence of DHA supplementation during pregnancy on language development across childhood: follow-up of a randomised controlled trial |
Author: | Gawlik, N.R. Makrides, M. Kettler, L. Yelland, L.N. Leemaqz, S. Gould, J.F. |
Citation: | Prostaglandins, Leukotrienes and Essential Fatty Acids, 2020; 163:102207-1-102207-12 |
Publisher: | Elsevier |
Issue Date: | 2020 |
ISSN: | 0952-3278 1532-2823 |
Statement of Responsibility: | N.R. Gawlik, M. Makrides, L. Kettler, L.N. Yelland, S. Leemaqz, J.F. Gould |
Abstract: | Numerous randomised controlled trials have explored the effect of docosahexaenoic acid (DHA) supplementation in early life on neurodevelopment, with some suggested positive effects on language. Australian women with a singleton pregnancy <21 weeks' gestation were randomised to receive 800 mg DHA/day or a placebo until birth. A sample of 726 children (all n=96 born preterm, random sample of n=630 born at term) were invited to undergo assessments of language, academic, and language-based cognitive abilities at 1.5, four and seven years of age. No group differences were detected for any group comparison. Exploratory analyses for sex by treatment interactions revealed a possible adverse effect of DHA supplementation on the language of females at 1.5 years but no effects on outcomes at four or seven years. Taken as a whole, evidence of an effect of prenatal DHA supplementation on language abilities across childhood is negligible and could be a chance finding. |
Keywords: | DHA; omega-3 fatty acids; pregnancy; supplementation; language; verbal abilities |
Rights: | © 2020 Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.plefa.2020.102207 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1061704 http://purl.org/au-research/grants/nhmrc/1052388 http://purl.org/au-research/grants/nhmrc/349301 http://purl.org/au-research/grants/nhmrc/627174 http://purl.org/au-research/grants/nhmrc/1048493 |
Published version: | http://dx.doi.org/10.1016/j.plefa.2020.102207 |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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