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Type: Journal article
Title: Structural organization of the mouse and human GALR1 Galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene
Author: Jacoby, A.
Webb, G.
Liu, M.
Kofler, B.
Hort, Y.
Fathi, Z.
Bottema, C.
Shine, J.
Iismaa, T.
Citation: Genomics, 1997; 45(3):496-508
Issue Date: 1997
ISSN: 0888-7543
Statement of
Jacoby, Arie S. ; Webb, Graham C. ; Liu, Marjorie L. ; Kofler, Barbara ; Hort, Yvonne J. ; Fathi, Zahra ; Bottema, Cynthia D.K. ; Shine, John ; Iismaa, Tiina P.
Abstract: The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Human and rat GALR1 galanin receptor cDNA clones have previously been isolated using expression cloning. We have used the human GALR1 cDNA in hybridization screening to isolate the gene encoding GALR1 in both human (GALNR) and mouse (Galnr). The gene spans approximately 15-20 kb in both species; its structural organization is conserved and is unique among G-protein-coupled receptors. The coding sequence is contained on three exons, with exon 1 encoding the N-terminal end of the receptor and the first five transmembrane domains. Exon 2 encodes the third intracellular loop, while exon 3 encodes the remainder of the receptor, from transmembrane domain 6 to the C-terminus of the receptor protein. The mouse and human GALR1 receptor proteins are 348 and 349 amino acids long, respectively, and display 93% identity at the amino acid level. The mouse Galnr gene has been localized to Chromosome 18E4, homoeologous with the previously reported localization of the human GALNR gene to 18q23 in the same syntenic group as the genes encoding nuclear factor of activated T-cells, cytoplasmic 1, and myelin basic protein.
Keywords: Animals
Mice, Inbred BALB C
Mice, Inbred C57BL
Receptors, Galanin
Receptors, Gastrointestinal Hormone
DNA, Complementary
Chromosome Mapping
Cloning, Molecular
Amino Acid Sequence
Base Sequence
Conserved Sequence
Sequence Homology, Amino Acid
Molecular Sequence Data
DOI: 10.1006/geno.1997.4960
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