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https://hdl.handle.net/2440/132812
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Type: | Journal article |
Title: | MicroRNA-124 and microRNA-146a both attenuate persistent neuropathic pain induced by morphine in male rats |
Author: | Grace, P.M. Strand, K.A. Galer, E.L. Maier, S.F. Watkins, L.R. |
Citation: | Brain Research, 2018; 1692:9-11 |
Publisher: | Elsevier |
Issue Date: | 2018 |
ISSN: | 0006-8993 1872-6240 |
Statement of Responsibility: | Peter M. Grace, Keith A. Strand, Erika L. Galer, Steven F. Maier, Linda R. Watkins |
Abstract: | We have recently reported that a short course of morphine, starting 10 days after sciatic chronic constriction injury (CCI), prolonged the duration of mechanical allodynia for months after morphine ceased. Maintenance of this morphine-induced persistent sensitization was dependent on microglial reactivity and Toll-like receptor 4 signaling. Given that microRNAs (miRNAs) such as miR-124 and miR-146a possess the ability to modulate such signaling, we directly compared their function in this model. We found that both miRNAs reversed established allodynia in our model of morphine-induced persistent sensitization. The efficacy of miR-124 and miR-146a were comparable, and in both cases allodynia returned within hours to days of miRNA dosing conclusion. Our findings demonstrate that miRNAs targeting Toll-like receptor signaling are effective in reversing neuropathic pain, which underscores the clinical potential of these non-coding RNAs. |
Keywords: | TLR4; P2X7R; danger signals; priming; opioid-induced hyperalgesia |
Rights: | © 2018 Elsevier B.V. All rights reserved. |
DOI: | 10.1016/j.brainres.2018.04.038 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1054091 |
Published version: | http://dx.doi.org/10.1016/j.brainres.2018.04.038 |
Appears in Collections: | Medicine publications |
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