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https://hdl.handle.net/2440/13292
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Type: | Journal article |
Title: | An orphaned mammalian b-globin gene of ancient evolutionary origin |
Author: | Wheeler, D. Hope, R. Cooper, S. Dolman, G. Webb, G. Bottema, C. Gooley, A. Goodman, M. Holland, R. |
Citation: | Proceedings of the National Academy of Sciences of USA, 2001; 98(3):1101-1106 |
Publisher: | Natl Acad Sciences |
Issue Date: | 2001 |
ISSN: | 0027-8424 1091-6490 |
Statement of Responsibility: | David Wheeler; Rory Hope; Steven J. B. Cooper; Gaynor Dolman; Graham C. Webb; Cynthia D. K. Bottema; Andrew A. Gooley; Morris Goodman and Robert A. B. Holland |
Abstract: | Mammals possess multiple, closely linked β-globin genes that differ in the timing of their expression during development. These genes have been thought to be derived from a single ancestral gene, by duplication events that occurred after the separation of the mammals and birds. We report the isolation and characterization of an atypical β-like globin gene (ω-globin) in marsupials that appears to be more closely related to avian β-globin genes than to other mammalian β-globin genes, including those previously identified in marsupials. Phylogenetic analyses indicate that ω-globin evolved from an ancient gene duplication event that occurred before the divergence of mammals and birds. Furthermore, we show that ω-globin is unlinked to the previously characterized β-globin gene cluster of marsupials, making this the first report of an orphaned β-like globin gene expressed in a vertebrate. |
Keywords: | Animals Mammals Marsupialia Humans Globins Cloning, Molecular Polymerase Chain Reaction Sequence Alignment Evolution, Molecular Phylogeny Gene Duplication Amino Acid Sequence Base Sequence Molecular Sequence Data |
Description: | © 2001 National Academy of Sciences |
DOI: | 10.1073/pnas.98.3.1101 |
Published version: | http://www.jstor.org/stable/3054828 |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 7 Environment Institute Leaders publications Environment Institute publications Molecular and Biomedical Science publications |
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