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Type: Journal article
Title: An orphaned mammalian b-globin gene of ancient evolutionary origin
Author: Wheeler, D.
Hope, R.
Cooper, S.
Dolman, G.
Webb, G.
Bottema, C.
Gooley, A.
Goodman, M.
Holland, R.
Citation: Proceedings of the National Academy of Sciences of USA, 2001; 98(3):1101-1106
Publisher: Natl Acad Sciences
Issue Date: 2001
ISSN: 0027-8424
Statement of
David Wheeler; Rory Hope; Steven J. B. Cooper; Gaynor Dolman; Graham C. Webb; Cynthia D. K. Bottema; Andrew A. Gooley; Morris Goodman and Robert A. B. Holland
Abstract: Mammals possess multiple, closely linked β-globin genes that differ in the timing of their expression during development. These genes have been thought to be derived from a single ancestral gene, by duplication events that occurred after the separation of the mammals and birds. We report the isolation and characterization of an atypical β-like globin gene (ω-globin) in marsupials that appears to be more closely related to avian β-globin genes than to other mammalian β-globin genes, including those previously identified in marsupials. Phylogenetic analyses indicate that ω-globin evolved from an ancient gene duplication event that occurred before the divergence of mammals and birds. Furthermore, we show that ω-globin is unlinked to the previously characterized β-globin gene cluster of marsupials, making this the first report of an orphaned β-like globin gene expressed in a vertebrate.
Keywords: Animals
Cloning, Molecular
Polymerase Chain Reaction
Sequence Alignment
Evolution, Molecular
Gene Duplication
Amino Acid Sequence
Base Sequence
Molecular Sequence Data
Description: © 2001 National Academy of Sciences
DOI: 10.1073/pnas.98.3.1101
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