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https://hdl.handle.net/2440/133640
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dc.contributor.author | Nguyen, P.D. | - |
dc.contributor.author | Gurevich, D.B. | - |
dc.contributor.author | Sonntag, C. | - |
dc.contributor.author | Hersey, L. | - |
dc.contributor.author | Alaei, S. | - |
dc.contributor.author | Nim, H.T. | - |
dc.contributor.author | Siegel, A. | - |
dc.contributor.author | Hall, T.E. | - |
dc.contributor.author | Rossello, F.J. | - |
dc.contributor.author | Boyd, S.E. | - |
dc.contributor.author | Polo, J.M. | - |
dc.contributor.author | Currie, P.D. | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Cell Stem Cell, 2017; 21(1):107-119 | - |
dc.identifier.issn | 1934-5909 | - |
dc.identifier.issn | 1875-9777 | - |
dc.identifier.uri | https://hdl.handle.net/2440/133640 | - |
dc.description.abstract | Organ growth requires a careful balance between stem cell self-renewal and lineage commitment to ensure proper tissue expansion. The cellular and molecular mechanisms that mediate this balance are unresolved in most organs, including skeletal muscle. Here we identify a long-lived stem cell pool that mediates growth of the zebrafish myotome. This population exhibits extensive clonal drift, shifting from random deployment of stem cells during development to reliance on a small number of dominant clones to fuel the vast majority of muscle growth. This clonal drift requires Meox1, a homeobox protein that directly inhibits the cell-cycle checkpoint gene ccnb1. Meox1 initiates G<sub>2</sub> cell-cycle arrest within muscle stem cells, and disrupting this G<sub>2</sub> arrest causes premature lineage commitment and the resulting defects in muscle growth. These findings reveal that distinct regulatory mechanisms orchestrate stem cell dynamics during organ growth, beyond the G<sub>0</sub>/G<sub>1</sub> cell-cycle inhibition traditionally associated with maintaining tissue-resident stem cells. | - |
dc.description.statementofresponsibility | Phong Dang Nguyen, David Baruch Gurevich, Carmen Sonntag, Lucy Hersey, Sara Alaei, Hieu Tri Nim ... al et. | - |
dc.language.iso | en | - |
dc.publisher | Cell Press | - |
dc.rights | © 2017 Published by Elsevier Inc. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.stem.2017.06.003 | - |
dc.subject | Cell Line | - |
dc.subject | Myoblasts | - |
dc.subject | Animals | - |
dc.subject | Zebrafish | - |
dc.subject | Mice | - |
dc.subject | Homeodomain Proteins | - |
dc.subject | Zebrafish Proteins | - |
dc.subject | Cell Lineage | - |
dc.subject | Cyclin B1 | - |
dc.subject | G2 Phase Cell Cycle Checkpoints | - |
dc.subject.mesh | Cell Line | - |
dc.subject.mesh | Myoblasts | - |
dc.subject.mesh | Animals | - |
dc.subject.mesh | Zebrafish | - |
dc.subject.mesh | Mice | - |
dc.subject.mesh | Homeodomain Proteins | - |
dc.subject.mesh | Zebrafish Proteins | - |
dc.subject.mesh | Cell Lineage | - |
dc.subject.mesh | Cyclin B1 | - |
dc.subject.mesh | G2 Phase Cell Cycle Checkpoints | - |
dc.subject.mesh | Transcription Factors | - |
dc.title | Muscle stem cells undergo extensive clonal drift during tissue growth via meox1-mediated induction of G2 cell-cycle arrest | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.stem.2017.06.003 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Polo, J.M. [0000-0002-2531-778X] | - |
Appears in Collections: | Zoology publications |
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