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https://hdl.handle.net/2440/136047
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Type: | Journal article |
Title: | Comorbidities and quality of life in Australian men and women with diagnosed and undiagnosed high-risk obstructive sleep apnea |
Author: | Krishnan, S. Chai-Coetzer, C.L. Grivell, N. Lovato, N. Mukherjee, S. Vakulin, A. Adams, R.J. Appleton, S.L. |
Citation: | The Journal of Clinical Sleep Medicine, 2022; 18(7):1757-1767 |
Publisher: | American Academy of Sleep Medicine |
Issue Date: | 2022 |
ISSN: | 1550-9389 1550-9397 |
Statement of Responsibility: | Sowmya Krishnan, MBBS, Ching Li Chai-Coetzer, MBBS, PhD, Nicole Grivell, BHealth Sci, Honours, Nicole Lovato, PhD, Sutapa Mukherjee, MBBS, PhD, Andrew Vakulin, PhD, Robert J. Adams, MBBS, MD, Sarah L. Appleton, PhD |
Abstract: | Study Objectives: In a population-based survey, we determined sex differences in health profiles and quality of life between individuals who have a confirmed diagnosis of obstructive sleep apnea (OSA) and those who are at high risk of OSA yet remain undiagnosed. Methods: An online survey of Australian adults ≥ 18 years (n = 3,818) identified participants with self-reported diagnosed OSA (n = 460) or high-risk, undiagnosed OSA (OSA50 score ≥ 5, n = 1,015). Ever-diagnosed comorbidities, sociodemographics, and quality of life (EQ-5D-5L, Functional Outcomes of Sleep Questionnaire-10) were assessed. Results: Women were more frequently represented in the high-OSA-risk group compared with those with diagnosed OSA (55.5%, n = 563, versus 43%, n = 198; P < .001). In sex-specific logistic regression analyses, diagnosed OSA was associated with increased likelihoods of ≥ 1 cardiovascular condition (odds ratio: 3.0; 95% confidence interval: 2.0–4.5), hypertension (1.9; 1.3–2.8), gout (1.8; 1.1–2.9), and chronic obstructive pulmonary disease (3.8; 2.1–6.9) in men. In women, an association with asthma (2.0; 1.3–3.0) was seen. Diabetes, arthritis, mental health conditions (ever-diagnosed), and all EQ-5D-5L dimensions were associated with an OSA diagnosis regardless of sex, except for EQ-5D-5L anxiety/depression, which was only associated with an OSA diagnosis in women. A diagnosis of OSA was associated with sleepiness-related impairment (lowest quartile of Functional Outcomes of Sleep Questionnaire-10) in men (1.6; 1.01–2.5) and women (2.2; 1.4–3.6). Conclusions: Sex-specific health conditions may drive diagnosis of OSA; however, clinical suspicion of OSA needs to be increased in men and women. The impaired quality of life and persistent sleepiness in participants with diagnosed OSA observed at a population level requires greater clinical attention. Citation: Krishnan S, Chai-Coetzer CL, Grivell N, et al. Comorbidities and quality of life in Australian men and women with diagnosed and undiagnosed high-risk obstructive sleep apnea. |
Keywords: | Humans Sleep Apnea, Obstructive Comorbidity Quality of Life Adult Australia Female Male Sleepiness |
Rights: | © 2022 American Academy of Sleep Medicine |
DOI: | 10.5664/jcsm.9972 |
Published version: | http://dx.doi.org/10.5664/jcsm.9972 |
Appears in Collections: | Medicine publications |
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