Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/138840
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Type: | Journal article |
Title: | Prediction of Prostate Cancer Biochemical and Clinical Recurrence Is Improved by IHC-Assisted Grading Using Appl1, Sortilin and Syndecan-1. |
Author: | Logan, J.M. Hopkins, A.M. Martini, C. Sorvina, A. Tewari, P. Prabhakaran, S. Huzzell, C. Johnson, I.R.D. Hickey, S.M. Ung, B.S.-Y. Lazniewska, J. Brooks, R.D. Moore, C.R. Caruso, M.C. Karageorgos, L. Martin, C.M. O'Toole, S. Bogue Edgerton, L. Ward, M.P. Bates, M. et al. |
Citation: | Cancers, 2023; 15(12):1-12 |
Publisher: | MDPI AG |
Issue Date: | 2023 |
ISSN: | 2072-6694 2072-6694 |
Statement of Responsibility: | Jessica M. Logan ... Lisa M. Butler ... Douglas A. Brooks ... et al. |
Abstract: | Gleason scoring is used within a five-tier risk stratification system to guide therapeutic decisions for patients with prostate cancer. This study aimed to compare the predictive performance of routine H&E or biomarker-assisted ISUP (International Society of Urological Pathology) grade grouping for assessing the risk of biochemical recurrence (BCR) and clinical recurrence (CR) in patients with prostate cancer. This retrospective study was an assessment of 114 men with prostate cancer who provided radical prostatectomy samples to the Australian Prostate Cancer Bioresource between 2006 and 2014. The prediction of CR was the primary outcome (median time to CR 79.8 months), and BCR was assessed as a secondary outcome (median time to BCR 41.7 months). The associations of (1) H&E ISUP grade groups and (2) modified ISUP grade groups informed by the Appl1, Sortilin and Syndecan-1 immunohistochemistry (IHC) labelling were modelled with BCR and CR using Cox proportional hazard approaches. IHC-assisted grading was more predictive than H&E for BCR (C-statistic 0.63 vs. 0.59) and CR (C-statistic 0.71 vs. 0.66). On adjusted analysis, IHC-assisted ISUP grading was independently associated with both outcome measures. IHC-assisted ISUP grading using the biomarker panel was an independent predictor of individual BCR and CR. Prospective studies are needed to further validate this biomarker technology and to define BCR and CR associations in real-world cohorts. |
Keywords: | biomarkers clinical recurrence diagnosis prognosis prostate cancer |
Rights: | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). |
DOI: | 10.3390/cancers15123215 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/GNT1092904 http://purl.org/au-research/grants/nhmrc/2008119 |
Published version: | http://dx.doi.org/10.3390/cancers15123215 |
Appears in Collections: | Medicine publications |
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