Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/139012
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dc.contributor.author | Vince, J.E. | - |
dc.contributor.author | De Nardo, D. | - |
dc.contributor.author | Gao, W. | - |
dc.contributor.author | Vince, A.J. | - |
dc.contributor.author | Hall, C. | - |
dc.contributor.author | McArthur, K. | - |
dc.contributor.author | Simpson, D. | - |
dc.contributor.author | Vijayaraj, S. | - |
dc.contributor.author | Lindqvist, L.M. | - |
dc.contributor.author | Bouillet, P. | - |
dc.contributor.author | Rizzacasa, M.A. | - |
dc.contributor.author | Man, S.M. | - |
dc.contributor.author | Silke, J. | - |
dc.contributor.author | Masters, S.L. | - |
dc.contributor.author | Lessene, G. | - |
dc.contributor.author | Huang, D.C.S. | - |
dc.contributor.author | Gray, D.H.D. | - |
dc.contributor.author | Kile, B.T. | - |
dc.contributor.author | Shao, F. | - |
dc.contributor.author | Lawlor, K.E. | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Cell Reports, 2018; 25(9):2339-2353.e4 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | https://hdl.handle.net/2440/139012 | - |
dc.description | Published: November 27, 2018 | - |
dc.description.abstract | Intrinsic apoptosis resulting from BAX/BAK-mediated mitochondrial membrane damage is regarded as immunologically silent. We show here that in macrophages, BAX/BAK activation results in inhibitor of apoptosis (IAP) protein degradation to promote caspase-8-mediated activation of IL-1β. Furthermore, BAX/BAK signaling induces a parallel pathway to NLRP3 inflammasome-mediated caspase-1-dependent IL-1β maturation that requires potassium efflux. Remarkably, following BAX/BAK activation, the apoptotic executioner caspases, caspase-3 and -7, act upstream of both caspase-8 and NLRP3-induced IL-1β maturation and secretion. Conversely, the pyroptotic cell death effectors gasdermin D and gasdermin E are not essential for BAX/BAK-induced IL-1β release. These findings highlight that innate immune cells undergoing BAX/BAK-mediated apoptosis have the capacity to generate pro-inflammatory signals and provide an explanation as to why IL-1β activation is often associated with cellular stress, such as during chemotherapy. | - |
dc.description.statementofresponsibility | James E. Vince, Dominic De Nardo, Wenqing Gao, Angelina J. Vince, Cathrine Hall, Kate McArthur, Daniel Simpson, Swarna Vijayaraj, Lisa M. Lindqvist, Philippe Bouillet, Mark A. Rizzacasa, Si Ming Man, John Silke, Seth L. Masters, Guillaume Lessene, David C.S. Huang, Daniel H.D. Gray, Benjamin T. Kile, Feng Shao, and Kate E. Lawlor | - |
dc.language.iso | en | - |
dc.publisher | Cell Press | - |
dc.rights | © 2018 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | - |
dc.source.uri | http://dx.doi.org/10.1016/j.celrep.2018.10.103 | - |
dc.subject | mitochondria | - |
dc.subject.mesh | Mitochondria | - |
dc.subject.mesh | Macrophages | - |
dc.subject.mesh | Animals | - |
dc.subject.mesh | Mice | - |
dc.subject.mesh | Caspases | - |
dc.subject.mesh | Signal Transduction | - |
dc.subject.mesh | Apoptosis | - |
dc.subject.mesh | Enzyme Activation | - |
dc.subject.mesh | bcl-2 Homologous Antagonist-Killer Protein | - |
dc.subject.mesh | bcl-2-Associated X Protein | - |
dc.subject.mesh | Caspase 8 | - |
dc.subject.mesh | Caspase 3 | - |
dc.subject.mesh | Interleukin-1beta | - |
dc.subject.mesh | Caspase 7 | - |
dc.subject.mesh | Inflammasomes | - |
dc.subject.mesh | Proteolysis | - |
dc.subject.mesh | Protein Aggregates | - |
dc.subject.mesh | NLR Family, Pyrin Domain-Containing 3 Protein | - |
dc.title | The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation | - |
dc.title.alternative | The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1beta Activation | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.celrep.2018.10.103 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1101405 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1145788 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1099262 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1078763 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1046010 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1051506 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1127885 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1052598 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1141466 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1016647 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1090236 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1107149 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1042629 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/461221 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1113133 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Kile, B.T. [0000-0002-8836-8947] | - |
Appears in Collections: | Medicine publications |
Files in This Item:
File | Description | Size | Format | |
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hdl_139012.pdf | Published version | 5.02 MB | Adobe PDF | View/Open |
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