Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/14758
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Skeletal muscle kinetics of propofol in anaesthetized sheep: effect of altered muscle blood flow |
Author: | Zheng, D. Upton, R. Martinez, A. |
Citation: | Xenobiotica: the fate of foreign compounds in biological systems, 2000; 30(11):1079-1090 |
Publisher: | Taylor & Francis Ltd |
Issue Date: | 2000 |
ISSN: | 0049-8254 1366-5928 |
Abstract: | 1. The kinetics of propofol were studied in vivo in a skeletal muscle bed of the hindlimb of the anaesthetized sheep at normal and low rates of blood flow. 2. Propofol kinetics in muscle were determined during and after a 20-min i.v. infusion of propofol (10 mg min-1) via paired arteriofemoral venous blood sampling. One-and-a-half hours later, the study was repeated but with a concurrent left femoral artery infusion of adrenaline (0.004 mg min-1) to lower the muscle blood flow by vasoconstriction. 3. Muscle blood flow in the low flow state was 28% of that in the normal state. The kinetics were poorly described by a single flow-limited compartment model, but were better described by a model with a flow-limited component and a deeper distribution component. There were no significant differences in muscle retention of propofol between normal and low flow states. 4. There was an apparent arteriovenous shunt of approximately 24% of total muscle blood flow for the low flow state, but not for the normal blood flow state. |
Keywords: | Muscles Muscle, Skeletal Animals Sheep Epinephrine Propofol Adrenergic Agonists Anesthetics, Intravenous Area Under Curve Models, Statistical Oxygen Consumption Kinetics Hydrogen-Ion Concentration Time Factors Hemodynamics |
DOI: | 10.1080/00498250010006582 |
Published version: | http://dx.doi.org/10.1080/00498250010006582 |
Appears in Collections: | Anaesthesia and Intensive Care publications Aurora harvest 7 |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.