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Type: Journal article
Title: Skeletal muscle kinetics of propofol in anaesthetized sheep: effect of altered muscle blood flow
Author: Zheng, D.
Upton, R.
Martinez, A.
Citation: Xenobiotica, 2000; 30(11):1079-1090
Publisher: Taylor & Francis Ltd
Issue Date: 2000
ISSN: 0049-8254
Abstract: 1. The kinetics of propofol were studied in vivo in a skeletal muscle bed of the hindlimb of the anaesthetized sheep at normal and low rates of blood flow. 2. Propofol kinetics in muscle were determined during and after a 20-min i.v. infusion of propofol (10 mg min-1) via paired arteriofemoral venous blood sampling. One-and-a-half hours later, the study was repeated but with a concurrent left femoral artery infusion of adrenaline (0.004 mg min-1) to lower the muscle blood flow by vasoconstriction. 3. Muscle blood flow in the low flow state was 28% of that in the normal state. The kinetics were poorly described by a single flow-limited compartment model, but were better described by a model with a flow-limited component and a deeper distribution component. There were no significant differences in muscle retention of propofol between normal and low flow states. 4. There was an apparent arteriovenous shunt of approximately 24% of total muscle blood flow for the low flow state, but not for the normal blood flow state.
Keywords: Muscles; Muscle, Skeletal; Animals; Sheep; Epinephrine; Propofol; Adrenergic Agonists; Anesthetics, Intravenous; Area Under Curve; Models, Statistical; Oxygen Consumption; Kinetics; Hydrogen-Ion Concentration; Time Factors; Hemodynamics
RMID: 0001000814
DOI: 10.1080/00498250010006582
Appears in Collections:Anaesthesia and Intensive Care publications

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