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https://hdl.handle.net/2440/16671
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Type: | Journal article |
Title: | Phase I/II study of immunotherapy with T-cell peptide epitopes in patients with stage IV melanoma |
Author: | Hersey, P. Menzies, S. Coventry, B. Nguyen, T. Farrelly, M. Collins, S. Hirst, D. Johnson, H. |
Citation: | Cancer Immunology Immunotherapy, 2005; 54(3):208-218 |
Publisher: | Springer-Verlag |
Issue Date: | 2005 |
ISSN: | 0340-7004 1432-0851 |
Statement of Responsibility: | Peter Hersey, Scott W. Menzies, Brendon Coventry, Tam Nguyen, Margaret Farrelly, Susan Collins, Debbie Hirst and Heather Johnson |
Abstract: | Previous studies in small groups of patients suggested that immunization of melanoma patients with peptide epitopes recognized by T cells could induce regression of melanoma. This approach was tested in 36 patients with stage IV melanoma. The (MHC class I– restricted) peptides were from gp100, MART-1, tyrosinase, and MAGE-3. The gp100 and MART-1 peptides had been modified to increase their immunogenicity. In half the patients (groups 3 and 4) the peptides were given in the adjuvant Montanide-ISA-720, and half the patients in both groups were given GM-CSF s.c. for 4 days following each injection. Treatment was well tolerated except for two severe erythematous responses to Montanide- ISA-720 and marked inflammatory responses at sites of GM-CSF administration in three patients. There were no objective clinical responses but stabilization of disease for periods from 3 to 12 months were seen in seven patients. Five of these were patients given the peptides in Montanide-ISA-720. Delayed-type hypersensitivity (DTH) skin test responses were also seen mainly in the patients given the peptides in Montanide- ISA-720. GM-CSF did not increase DTH responses in patients in the latter group but may have increased DTH responses in those not given peptides in Montanide-ISA- 720. Inflammatory responses around s.c. metastases or regional lymph nodes were observed in two patients. These results suggest that the peptides are more effective when given in the adjuvant Montanide-ISA-720. Nevertheless, results from this study, together with those from a number of comparable studies, indicate that peptide vaccines are currently of minimal benefit to patients and support the need for ongoing development of new strategies in treatment of this disease. |
Keywords: | Adjuvants Clinical responses Melanoma Peptide vaccines T-cell responses |
Description: | © Springer-Verlag 2004 |
DOI: | 10.1007/s00262-004-0587-8 |
Published version: | http://dx.doi.org/10.1007/s00262-004-0587-8 |
Appears in Collections: | Aurora harvest 2 Surgery publications |
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