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Type: Journal article
Title: Progesterone supplementation for preventing preterm birth: a systematic review and meta-analysis
Author: Dodd, J.
Crowther, C.
Cincotta, R.
Flenady, V.
Robinson, J.
Citation: Acta Obstetricia et Gynecologica Scandinavica, 2005; 84(6):526-533
Publisher: Munksgaard Int Publ Ltd
Issue Date: 2005
ISSN: 0001-6349
Statement of
Jodie M. Dodd, Caroline A. Crowther, Robert Cincotta, Vicki Flenady, Jeffrey S. Robinson
Abstract: <h4>Aim</h4>The aim of this study is to assess the role of progesterone in preterm birth prevention.<h4>Methods</h4>A MEDLINE search (from 1966 to the present; date of last search January 2005) was performed - using the key words progesterone, pregnancy, preterm birth, preterm labor, and randomized, controlled trial - in order to identify randomized, controlled trials in which progesterone (either intramuscular or vaginal administration) was compared with placebo or no treatment. Data were extracted and a meta-analysis was performed.<h4>Results</h4>Seven randomized, controlled trials were identified. Women who received progesterone were statistically significantly less likely to give birth before 37 weeks (seven studies, 1020 women, RR = 0.58, 95% CI = 0.48-0.70), to have an infant with birth weight of < or =2.5 kg (six studies, 872 infants, RR = 0.62, 95% CI = 0.49-0.78), or to have an infant diagnosed with intraventricular hemorrhage (one study, 458 infants, RR = 0.25, 95% CI = 0.08-0.82).<h4>Conclusions</h4>For progesterone supplementation to be advocated for women at the risk of preterm birth, the prolongation of gestation demonstrated in this meta-analysis must translate into improved infant outcomes, including a reduction in mortality. There is currently insufficient information to allow recommendations regarding the optimal dose, route, and timing of administration of progesterone supplementation.
Keywords: Humans
Birth Weight
Tocolytic Agents
Administration, Intravaginal
Gestational Age
Infant, Newborn
Obstetric Labor, Premature
Randomized Controlled Trials as Topic
Description: The definitive version is available at
DOI: 10.1111/j.0001-6349.2005.00835.x
Published version:
Appears in Collections:Aurora harvest 2
Obstetrics and Gynaecology publications

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