Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/17287
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Type: Journal article
Title: Vitamin E supplementation in pregnancy
Author: Rumbold, A.
Crowther, C.
Citation: The Cochrane Database of Systematic Reviews, 2005; Online(3):WWW1-WWW44
Publisher: Update Software Ltd
Issue Date: 2005
ISSN: 1469-493X
1469-493X
Statement of
Responsibility: 
Rumbold A, Crowther CA
Abstract: <h4>Background</h4>Vitamin C supplementation may help reduce the risk of pregnancy complications like pre-eclampsia, intrauterine growth restriction and maternal anaemia. There is a need to evaluate the efficacy and safety of vitamin C supplementation in pregnancy.<h4>Objectives</h4>To evaluate the effects of vitamin C supplementation, alone or in combination with other separate supplements, on pregnancy outcomes, adverse events, side-effects and use of health resources.<h4>Search strategy</h4>We searched the Cochrane Pregnancy and Childbirth Group Trials Register (23 June 2004), Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 2, 2004), MEDLINE, Current Contents and EMBASE.<h4>Selection criteria</h4>All randomised or quasi-randomised controlled trials evaluating vitamin C supplementation in pregnant women. Interventions using a multivitamin supplement containing vitamin C or where the primary supplement was iron were excluded.<h4>Data collection and analysis</h4>Two authors independently assessed trials for inclusion, extracted data and assessed trial quality.<h4>Main results</h4>Five trials, involving 766 women, are included in this review. No difference was seen between women supplemented with vitamin C alone or combined with other supplements compared with placebo for the risk of stillbirth (relative risk (RR) 0.87, 95% confidence intervals (CI) 0.41 to 1.87, three trials, 539 women), perinatal death (RR 1.16, 95% CI 0.61 to 2.18, two trials, 238 women), birthweight (weighted mean difference (WMD) -139.00 g, 95% CI -517.68 to 239.68, one trial, 100 women) or intrauterine growth restriction (RR 0.72, 95% CI 0.49 to 1.04, two trials, 383 women). Women supplemented with vitamin C alone or combined with other supplements were at increased risk of giving birth preterm (RR 1.38, 95% CI 1.04 to 1.82, three trials, 583 women). Significant heterogeneity was found for neonatal death and pre-eclampsia. No difference was seen between women supplemented with vitamin C combined with other supplements for the risk of neonatal death (RR 1.73, 95% CI 0.25 to 12.12, two trials, 221 women), using a random-effects model. For pre-eclampsia, women supplemented with vitamin C combined with other supplements were at decreased risk when using a fixed-effect model (RR 0.47, 95% CI 0.30 to 0.75, four trials, 710 women); however, this difference could not be demonstrated when using a random-effects model (RR 0.52, 95% CI 0.23 to 1.20, four trials, 710 women).<h4>Authors' conclusions</h4>The data are too few to say if vitamin C supplementation, alone or combined with other supplements, is beneficial during pregnancy. Preterm birth may have been increased with vitamin C supplementation.
Keywords: Humans; Pregnancy Complications; Fetal Death; Pre-Eclampsia; Premature Birth; Ascorbic Acid; Pregnancy Outcome; Pregnancy; Dietary Supplements; Infant, Newborn; Female; Randomized Controlled Trials as Topic
Description: Copyright © 2008 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
RMID: 0020051323
DOI: 10.1002/14651858.CD004069
Published version: http://www.cochrane.org/reviews/en/ab004069.html
Appears in Collections:Obstetrics and Gynaecology publications

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