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https://hdl.handle.net/2440/17374
Type: | Journal article |
Title: | Differential expression of F-actin in in utero fetal wounds |
Author: | Cowin, A. |
Citation: | European Journal of Dermatology, 2005; 15(3):133-139 |
Publisher: | John Libbey Eurotext Ltd |
Issue Date: | 2005 |
ISSN: | 1167-1122 1952-4013 |
Abstract: | Fetal skin possesses the capacity to heal a wound by a process of regeneration rather than repair, resulting in the absence of scar formation. The actin cytoskeleton may be involved in this process of scar-free wound healing. The effect of wounding on the expression of contractile filamentous actin (F-actin) was investigated in utero in mice between embryonic day 16 (E16) and embryonic day 18 (E18). Increased F-actin staining in the epidermis of the E16 fetal wounds was observed as early as 3 hours post-wounding, peaking in intensity after 24 hours. By 48 hours the intensity of staining had returned to background levels. In marked contrast, E18 fetal wounds did not show increased epidermal F-actin fluorescence, instead increased staining was observed in cells lying perpendicular to the wound margin within the dermis. This developmental switch from epidermal actin expression in "scar-free" fetal wounds to dermal actin expression in late "scar-forming" gestation wounds may be important in fetal wound contraction and scar-free wound repair. |
Keywords: | Fetus Skin Animals Mice Prenatal Injuries Disease Models, Animal Actins Microscopy, Confocal Tissue and Organ Harvesting Sensitivity and Specificity Wound Healing Pregnancy Pregnancy, Animal Female Skin Physiological Phenomena Actin Cytoskeleton |
Appears in Collections: | Aurora harvest 6 Paediatrics publications |
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