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https://hdl.handle.net/2440/17451
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DC Field | Value | Language |
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dc.contributor.author | Korten, Z. | - |
dc.contributor.author | Cakouros, D. | - |
dc.contributor.author | Kumar, S. | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Journal of Biological Chemistry, 2005; 280(12):11981-11986 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.issn | 1083-351X | - |
dc.identifier.uri | http://hdl.handle.net/2440/17451 | - |
dc.description.abstract | The Drosophila steroid hormone ecdysone mediates cell death during metamorphosis by regulating the transcription of a number of cell death genes. The apical caspase DRONC is known to be transcriptionally regulated by ecdysone during development. Here we demonstrate that ecdysone also regulates the transcription of DRICE, a major effector caspase and a downstream target for DRONC in the fly. Using RNA interference in an ecdysone-responsive Drosophila cell line, we show that drice up-regulation is essential for apoptosis induced by ecdysone. We also show that drice expression is specifically controlled by the ecdysone-regulated transcription factor BR-C. Combined with previous observations, our results indicate that transcriptional regulation of the components of the core apoptotic machinery plays a key role in hormone-regulated programmed cell death during Drosophila development. | - |
dc.language.iso | en | - |
dc.publisher | Amer Soc Biochemistry Molecular Biology Inc | - |
dc.source.uri | http://dx.doi.org/10.1074/jbc.m413971200 | - |
dc.subject | Salivary Glands | - |
dc.subject | Cells, Cultured | - |
dc.subject | Animals | - |
dc.subject | Drosophila | - |
dc.subject | Ecdysone | - |
dc.subject | Caspases | - |
dc.subject | Drosophila Proteins | - |
dc.subject | Transcription Factors | - |
dc.subject | RNA, Messenger | - |
dc.subject | Apoptosis | - |
dc.subject | Up-Regulation | - |
dc.subject | Enzyme Activation | - |
dc.title | Ecdysone-mediated up-regulation of the effector caspase DRICE is required for hormone-dependent apoptosis in Drosophila cells | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1074/jbc.M413971200 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Cakouros, D. [0000-0001-6136-0761] | - |
dc.identifier.orcid | Kumar, S. [0000-0001-7126-9814] | - |
Appears in Collections: | Aurora harvest 2 Medicine publications |
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