Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/17453
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Type: Journal article
Title: Initially more rapid small intestinal glucose delivery increases plasma insulin, GIP and GLP-1 but does not improve overall glycemia in healthy subjects
Author: Chaikomin, R.
Doran, S.
Jones, K.
Feinle-Bisset, C.
O'Donovan, D.
Rayner, C.
Horowitz, M.
Citation: American Journal of Physiology-Endocrinology and Metabolism, 2005; 289(3):E504-E507
Publisher: Amer Physiological Soc
Issue Date: 2005
ISSN: 0193-1849
1522-1555
Statement of
Responsibility: 
Reawika Chaikomin, Selena Doran, Karen L. Jones, Christine Feinle-Bisset, Deirdre O’Donovan, Christopher K. Rayner, and Michael Horowitz
Abstract: The rate of gastric emptying of glucose-containing liquids is a major determinant of postprandial glycemia. The latter is also dependent on stimulation of insulin secretion by glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). Although overall emptying of glucose approximates 1–3 kcal/min, the “early phase” of gastric emptying is usually more rapid. We have evaluated the hypothesis that increased stimulation of incretin hormones and insulin by a more rapid initial rate of small intestinal glucose delivery would reduce the overall glycemic response to a standardized enteral glucose load. Twelve healthy subjects were studied on two separate days in which they received an intraduodenal (id) glucose infusion for 120 min. On one day, the infusion rate was variable, being more rapid (6 kcal/min) between t = 0 and 10 min and slower (0.55 kcal/min) between t = 10 and 120 min, whereas on the other day the rate was constant (1 kcal/min) from t = 0–120 min, i.e., on both days 120 kcal were given. Between t = 0 and 75 min, plasma insulin, GIP, and GLP-1 were higher with the variable infusion. Despite the increase in insulin and incretin hormones, blood glucose levels were also higher. Between t = 75 and 180 min, blood glucose and plasma insulin were lower with the variable infusion. There was no difference in the area under the curve 0–180 min for blood glucose. We conclude that stimulation of incretin hormone and insulin release by a more rapid initial rate of id glucose delivery does not lead to an overall reduction in glycemia in healthy subjects.
Keywords: intraduodenal glucose; incretin hormones
Description: Published abstract used with permission of the copyright owner.
Rights: Copyright © 2005 by the American Physiological Society
RMID: 0020050333
DOI: 10.1152/ajpendo.00099.2005
Appears in Collections:Medicine publications

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