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Type: Journal article
Title: Evaluation of interactions between CCK and GLP-1 in their effects on appetite, energy intake, and antropyloroduodenal motility in healthy men
Author: Brennan, I.
Feltrin, K.
Horowitz, M.
Smout, A.
Meyer, J.
Wishart, J.
Feinle-Bisset, C.
Citation: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 2005; 288(6):R1477-R1485
Publisher: Amer Physiological Soc
Issue Date: 2005
ISSN: 0363-6119
Statement of
Ixchel M. Brennan, Kate L. Feltrin, Michael Horowitz, Andre J. P. M. Smout, James H. Meyer, Judith Wishart, and Christine Feinle-Bisset
Abstract: There is evidence that CCK and glucagon-like peptide-1 (GLP-1) mediate the effects of nutrients on appetite and gastrointestinal function and that their interaction may be synergistic. We hypothesized that intravenous CCK-8 and GLP-1 would have synergistic effects on appetite, energy intake, and antropyloroduodenal (APD) motility. Nine healthy males (age 22 ± 1 yr) were studied on four separate days in a double-blind, randomized fashion. Appetite and APD pressures were measured during 150-min intravenous infusions of 1) isotonic saline (control), 2) CCK-8 (1.8 pmol·kg–1·min–1), 3) GLP-1 (0.9 pmol·kg–1·min–1), or 4) both CCK-8 (1.8 pmol·kg–1·min–1) and GLP-1 (0.9 pmol·kg–1·min–1). At 120 min, energy intake at a buffet meal was quantified. CCK-8, but not GLP-1, increased fullness, decreased desire to eat and subsequent energy intake, and increased the number and amplitude of isolated pyloric pressure waves and basal pyloric pressure (P < 0.05). Both CCK-8 and GLP-1 decreased the number of antral and duodenal pressure waves (PWs) (P < 0.05), and CCK-8+GLP-1 decreased the number of duodenal PWs more than either CCK-8 or GLP-1 alone (P < 0.02). This was not the case for appetite or isolated pyloric PWs. In conclusion, at the doses evaluated, exogenously administered CCK-8 and GLP-1 had discrepant effects on appetite, energy intake, and APD pressures, and the effects of CCK-8+GLP-1, in combination, did not exceed the sum of the effects of CCK-8 and GLP-1, providing no evidence of synergism.
Keywords: Duodenum
Pyloric Antrum
Peptide Fragments
Protein Precursors
Infusions, Intravenous
Double-Blind Method
Satiety Response
Energy Intake
Gastrointestinal Motility
Drug Synergism
Reference Values
Glucagon-Like Peptide 1
Description: Published abstract used with permission of the copyright owner.
Rights: Copyright © 2005 American Physiological Society
DOI: 10.1152/ajpregu.00732.2004
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