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|Title:||Evaluation of interactions between CCK and GLP-1 in their effects on appetite, energy intake, and antropyloroduodenal motility in healthy men|
|Citation:||American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 2005; 288(6):R1477-R1485|
|Publisher:||Amer Physiological Soc|
|Ixchel M. Brennan, Kate L. Feltrin, Michael Horowitz, Andre J. P. M. Smout, James H. Meyer, Judith Wishart, and Christine Feinle-Bisset|
|Abstract:||There is evidence that CCK and glucagon-like peptide-1 (GLP-1) mediate the effects of nutrients on appetite and gastrointestinal function and that their interaction may be synergistic. We hypothesized that intravenous CCK-8 and GLP-1 would have synergistic effects on appetite, energy intake, and antropyloroduodenal (APD) motility. Nine healthy males (age 22 ± 1 yr) were studied on four separate days in a double-blind, randomized fashion. Appetite and APD pressures were measured during 150-min intravenous infusions of 1) isotonic saline (control), 2) CCK-8 (1.8 pmol·kg–1·min–1), 3) GLP-1 (0.9 pmol·kg–1·min–1), or 4) both CCK-8 (1.8 pmol·kg–1·min–1) and GLP-1 (0.9 pmol·kg–1·min–1). At 120 min, energy intake at a buffet meal was quantified. CCK-8, but not GLP-1, increased fullness, decreased desire to eat and subsequent energy intake, and increased the number and amplitude of isolated pyloric pressure waves and basal pyloric pressure (P < 0.05). Both CCK-8 and GLP-1 decreased the number of antral and duodenal pressure waves (PWs) (P < 0.05), and CCK-8+GLP-1 decreased the number of duodenal PWs more than either CCK-8 or GLP-1 alone (P < 0.02). This was not the case for appetite or isolated pyloric PWs. In conclusion, at the doses evaluated, exogenously administered CCK-8 and GLP-1 had discrepant effects on appetite, energy intake, and APD pressures, and the effects of CCK-8+GLP-1, in combination, did not exceed the sum of the effects of CCK-8 and GLP-1, providing no evidence of synergism.|
|Keywords:||Duodenum; Pyloric Antrum; Humans; Nausea; Cholecystokinin; Glucagon; Peptide Fragments; Protein Precursors; Infusions, Intravenous; Double-Blind Method; Appetite; Satiety Response; Energy Intake; Gastrointestinal Motility; Drug Synergism; Pressure; Reference Values; Adolescent; Adult; Male; Glucagon-Like Peptide 1|
|Description:||Published abstract used with permission of the copyright owner.|
|Rights:||Copyright © 2005 American Physiological Society|
|Appears in Collections:||Medicine publications|
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