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https://hdl.handle.net/2440/17476
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Type: | Journal article |
Title: | Exogenously administered leptin leads to weight loss and increased physical activity in the marsupial Sminthopsis crassicaudata |
Author: | Wittert, G. Turnbull, H. Hope, P. |
Citation: | Physiology and Behavior, 2005; 85(5):613-620 |
Publisher: | Pergamon-Elsevier Science Ltd |
Issue Date: | 2005 |
ISSN: | 0031-9384 1873-507X |
Statement of Responsibility: | Gary A. Wittert, Helen Turnbull, Perdita Hope |
Abstract: | The adipose tissue derived cytokine leptin, modifies energy balance via effects on both food intake and energy expenditure. It is not clear, however, whether the component of energy expenditure accounted for by voluntary (nonexercise) physical activity is increased in response to leptin. The aim of this study was to investigate the effect of exogenously administered leptin on physical activity in the marsupial Sminthopsis crassicaudata. Body weight, tail width and food intake, were measured daily and physical activity was measured hourly in normal lean S. crassicaudata (n=8) with ad libitum access to standard laboratory diet. After 5 days baseline the animals were divided into two equal groups (n=4), and either human recombinant leptin (2.5 mg/kg) or placebo was administered twice daily intraperitoneally. Approximately 81% of the total daily activity during the baseline period occurred during the nocturnal phase. After 9 days of leptin administration, there were significant decreases in body weight (P<0.001) and fat content (P<0.01), which were not accompanied by a decrease in total energy intake. Overall daily physical activity increased (P=0.028); this effect was confined to the dark phase (P=0.033). We conclude that in lean S. crassicaudata the exogenous administration of human recombinant leptin results in a decrease in adiposity which occurs in the absence of a measurable effect on food intake and is associated with an increase in non-exercise physical activity at least over the duration of this study. |
Keywords: | Adipose Tissue Tail Animals Marsupialia Humans Body Weight Weight Loss Leptin Recombinant Proteins Motor Activity Circadian Rhythm Eating Male |
Description: | Copyright © 2005 Elsevier |
DOI: | 10.1016/j.physbeh.2005.06.012 |
Published version: | http://dx.doi.org/10.1016/j.physbeh.2005.06.012 |
Appears in Collections: | Aurora harvest 6 Medicine publications |
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