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Type: Journal article
Title: Palifermin for oral mucositis in the high-dose chemotherapy and stem cell transplant setting: the Royal Adelaide Hospital Cancer Centre experience
Author: Keefe, D.
Lees, J.
Horvath, N.
Citation: Supportive Care in Cancer, 2006; 14(6):580-582
Publisher: Springer-Verlag
Issue Date: 2006
ISSN: 0941-4355
Statement of
Dorothy Keefe, Jude Lees and Noemi Horvath
Abstract: Goals of work the aim of this paper was to review the initial use of Palifermin(rHu-KGF1) in a single institution, for the prevention of oral mucositis in high-dose chemotherapy and stem cell transplantation. Methods the case records of the first five patients treated with Palifermin at the Royal Adelaide Hospital Cancer Centre were reviewed, and incidence,severity and duration of the oral mucositis were recorded, as well as demographics and toxicities. Results two of the five patients developed grade 4 mucositis, and the remaining three patients developed grade 2 mucositis. Palifemin was well tolerated with only one patient developing a rash. Conclusions the severity of oral mucositis was less than would be expected in these patients without anti-mucositis therapy. Palifermin was well tolerated. Obviously this single institution report is from a very small cohort of patients, but it is encouraging for the ease of use of this drug in the future.
Keywords: Humans
Drug Eruptions
Antineoplastic Agents
Antineoplastic Combined Chemotherapy Protocols
Treatment Outcome
Transplantation Conditioning
Combined Modality Therapy
Hematopoietic Stem Cell Transplantation
Drug Administration Schedule
Severity of Illness Index
Primary Prevention
Time Factors
Middle Aged
Cancer Care Facilities
South Australia
Fibroblast Growth Factor 7
Description: The original publication can be found at
DOI: 10.1007/s00520-006-0048-3
Published version:
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