Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/23150
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Type: Journal article
Title: The association between inherited cytokine polymorphisms and cerebral palsy
Author: Gibson, C.
MacLennan, A.
Goldwater, P.
Haan, E.
Priest, K.
Dekker, G.
Hague, W.
Morton, M.
Citation: American Journal of Obstetrics and Gynecology, 2006; 194(3):674e1-674e11
Publisher: Mosby Inc
Issue Date: 2006
ISSN: 0002-9378
1097-6868
Statement of
Responsibility: 
Catherine S. Gibson, Alastair H. MacLennan, Paul N. Goldwater, Eric A. Haan, Kevin Priest, Gustaaf A. Dekker
Abstract: Objective The purpose of this study was to investigate associations between inherited cytokine polymorphisms and cerebral palsy. Study design This was a case-control study that used DNA from the newborn infant screening cards of 443 white infants with cerebral palsy and 883 white control infants to test for the following cytokine polymorphisms: tumor necrosis factor–alpha-308, mannose-binding lectin–221, and 3 polymorphisms in exon-1 of the mannose-binding lectin gene at codon-52, -54, and -57. Results At all gestational ages mannose-binding lectin codon-54 increased the risk of the development of diplegia (homozygous or heterozygous odds ratio, 1.55; 95% CI, 1.03-2.32). For babies who were born at term, the risk of the development of quadriplegia was associated with heterozygous tumor necrosis factor– α (odds ratio, 1.82; 95% CI, 1.04-3.15), and mannose-binding lectin codon-54 was associated with diplegia (homozygous or heterozygous odds ratio, 2.12; 95% CI, 1.10-4.05). The presence of any polymorphism in mannose-binding lectin exon–1 at term approximately doubled the risk of the development of diplegia (odds ratio, 1.94; 95% CI, 1.05-3.62). Homozygous or heterozygous tumor necrosis factor– α was associated with hemiplegia for babies who were born at <32 weeks of gestation (odds ratio, 2.38; 95% CI, 1.02-5.58). Overall, the presence of any cytokine polymorphism was associated with cerebral palsy (odds ratio, 1.37; 95% CI, 1.02-1.84). Conclusion Carriage of polymorphisms in the tumor necrosis factor– α and mannose-binding lectin genes are associated with an increased risk of cerebral palsy.
Keywords: Cerebral palsy; Tumor necrosis factor–α; Mannose-binding lectin; Polymorphism
RMID: 0020060322
DOI: 10.1016/j.ajog.2006.01.093
Description (link): http://www.elsevier.com/wps/find/journaldescription.cws_home/623277/description#description
Appears in Collections:Obstetrics and Gynaecology publications
Cerebral Palsy Research Group publications

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