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https://hdl.handle.net/2440/23172
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dc.contributor.author | Sferruzzi-Perri, A. | - |
dc.contributor.author | Owens, J. | - |
dc.contributor.author | Pringle, K. | - |
dc.contributor.author | Robinson, J. | - |
dc.contributor.author | Roberts, C. | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Endocrinology, 2006; 147(7):3344-3355 | - |
dc.identifier.issn | 0013-7227 | - |
dc.identifier.issn | 0013-7227 | - |
dc.identifier.uri | http://hdl.handle.net/2440/23172 | - |
dc.description | Copyright © 2006 by The Endocrine Society | - |
dc.description.abstract | The placenta transports substrates and wastes between the maternal and fetal circulations. In mice, placental IGF-II is essential for normal placental development and function but, in other mammalian species, maternal circulating IGF-II is substantial and may contribute. Maternal circulating IGFs increase in early pregnancy, and early treatment of guinea pigs with either IGF-I or IGF-II increases placental and fetal weights by mid-gestation. We now show that these effects persist to enhance placental development and fetal growth and survival near term. Pregnant guinea pigs were infused with IGF-I, IGF-II (both 1 mg/kg.d), or vehicle sc from d 20-38 of pregnancy and killed on d 62 (term = 69 d). IGF-II, but not IGF-I, increased the mid-sagittal area and volume of placenta devoted to exchange by approximately 30%, the total volume of trophoblast and maternal blood spaces within the placental exchange region (+29% and +46%, respectively), and the total surface area of placenta for exchange by 39%. Both IGFs reduced resorptions, and IGF-II increased the number of viable fetuses by 26%. Both IGFs increased fetal weight by 11-17% and fetal circulating amino acid concentrations. IGF-I, but not IGF-II, reduced maternal adipose depot weights by approximately 30%. In conclusion, increased maternal IGF-II abundance in early pregnancy promotes fetal growth and viability near term by increasing placental structural and functional capacity, whereas IGF-I appears to divert nutrients from the mother to the conceptus. This suggests major and complementary roles in placental and fetal growth for increased circulating IGFs in early to mid-pregnancy. | - |
dc.language.iso | en | - |
dc.publisher | Endocrine Soc | - |
dc.source.uri | http://dx.doi.org/10.1210/en.2005-1328 | - |
dc.subject | Trophoblasts | - |
dc.subject | Placenta | - |
dc.subject | Animals | - |
dc.subject | Guinea Pigs | - |
dc.subject | Mice | - |
dc.subject | Insulin-Like Growth Factor I | - |
dc.subject | Insulin-Like Growth Factor II | - |
dc.subject | Insulin-Like Growth Factor Binding Proteins | - |
dc.subject | Pregnancy Outcome | - |
dc.subject | Mothers | - |
dc.subject | Fetal Development | - |
dc.subject | Pregnancy | - |
dc.subject | Maternal-Fetal Exchange | - |
dc.subject | Pregnancy, Animal | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | Maternal insulin-like growth factors-I and -II act via different pathways to promote fetal growth | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1210/en.2005-1328 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Owens, J. [0000-0002-7498-1353] | - |
dc.identifier.orcid | Robinson, J. [0000-0002-4515-6039] | - |
dc.identifier.orcid | Roberts, C. [0000-0002-9250-2192] | - |
Appears in Collections: | Aurora harvest 6 Obstetrics and Gynaecology publications |
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