Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/23177
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Type: Journal article
Title: Short-term meal replacements followed by dietary macronutrient restriction enhance weight loss in polycystic ovary syndrome
Author: Moran, L.
Noakes, M.
Clifton, P.
Wittert, G.
Williams, G.
Norman, R.
Citation: American Journal of Clinical Nutrition, 2006; 84(1):77-87
Publisher: Amer Soc Clinical Nutrition
Issue Date: 2006
ISSN: 0002-9165
1938-3207
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Responsibility: 
Lisa J Moran, Manny Noakes, Peter M Clifton, Gary A Wittert, Gemma Williams, and Robert J Norman
Abstract: Polycystic ovary syndrome (PCOS), a common condition in women, improves with weight loss. Meal replacements in short-term weight loss and strategies for weight maintenance have not been investigated in PCOS.We compared in overweight women with PCOS the effects of meal replacements in short-term weight-loss and longer-term carbohydrate- or fat-restriction strategies on weight maintenance and improvements in reproductive and metabolic variables.Overweight women with PCOS (n = 43; x +/- SD age: 32.1 +/- 5.2 y; weight: 96.1 +/- 18.4 kg) followed an 8-wk weight-loss regimen (2 meal replacements/d, 4904.4 +/- 127 kJ; phase 1) and then a 6-mo weight-maintenance carbohydrate- (<120 g/d) or fat- (<50 g/d) restriction regimen (phase 2).Thirty-four women completed phase 1, and 23 women completed phase 2; the proportion of dropouts was similar in the 2 groups. During phase 1, significant (P < 0.05) reductions in weight (5.6 +/- 2.4 kg), waist circumference (6.1 +/- 2.5 cm), body fat (4.1 +/- 2.2 kg), insulin (2.8 +/- 1.1 mU/L), total testosterone (0.3 +/- 0.7 nmol/L), and free androgen index (3.1 +/- 4.6) occurred; these changes were sustained during phase 2. No significant differences between diet groups were seen for any variables. At 6 mo, both approaches resulted in a net weight loss of 4.7 +/- 4.6 kg. Improvements in menstrual cyclicity occurred for 16 (57.1%) of 28 subjects.Meal replacements are an effective strategy for the short-term management of PCOS. Advice on moderate fat or carbohydrate restriction was equally effective in maintaining weight reduction and improving reproductive and metabolic variables.
Keywords: polycystic ovary syndrome; weight loss; weight maintenance; glycemic index; meal replacement
Rights: Copyright © 2006 American Society for Nutrition
RMID: 0020061004
DOI: 10.1093/ajcn/84.1.77
Published version: http://www.ajcn.org/cgi/content/abstract/84/1/77
Appears in Collections:Obstetrics and Gynaecology publications

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