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Type: Journal article
Title: Placental malaria in women with South-East Asian ovalocytosis
Author: Benet, A.
Khong, T.
Ura, A.
Samen, R.
Lorry, K.
Mellombo, M.
Tavul, L.
Baea, K.
Rogerson, S.
Cortes, A.
Citation: American Journal of Tropical Medicine and Hygiene, 2006; 75(4):597-604
Publisher: Amer Soc Trop Med & Hygiene
Issue Date: 2006
ISSN: 0002-9637
Statement of
Ariadna Benet, T. Yee Khong, Alice Ura, Rebecca Samen, Kerry Lorry, Mata Mellombo, Livingstone Tavul, Key Baea, Stephen J. Rogerson, and Alfred Cortés
Abstract: Malaria during pregnancy, which is characterized by the accumulation of infected erythrocytes in the placenta, often has severe consequences for the mother and newborn. We assessed the effect of the genetic trait South-East Asian ovalocytosis (SAO) on placental malaria in women from Papua New Guinea. In children, this trait confers protection against cerebral malaria, but not against mild malaria disease, malaria parasitemia, or severe malaria anemia. Using a case-control approach, we found that SAO women suffer from placental malaria, and SAO-infected erythrocytes can sequester in the placenta, but heavy placental infections tended to be less common in SAO than in control pregnant women. Reduced prevalence and severity of placental infection associated with SAO were observed only for primigravid women, who are the group at highest risk of suffering from severe manifestations of placental malaria. Furthermore, we found that the prevalence of the SAO trait was lower among pregnant women than among non-pregnant controls.
Keywords: Placenta
Pregnancy Complications, Parasitic
Elliptocytosis, Hereditary
Birth Weight
Antibodies, Protozoan
Flow Cytometry
Case-Control Studies
Infant, Newborn
Papua New Guinea
Rights: Copyright 2006 The American Society of Tropical Medicine
DOI: 10.4269/ajtmh.2006.75.597
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Appears in Collections:Aurora harvest 2
Obstetrics and Gynaecology publications

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