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https://hdl.handle.net/2440/23295
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Type: | Journal article |
Title: | Effect of baclofen on esophagogastric motility and gastroesophageal reflux in children with gastroesophageal reflux disease: A randomized controlled trial |
Author: | Omari, T. Benninga, M. Sansom, L. Butler, R. Dent, J. Davidson, G. |
Citation: | Journal of Pediatrics, 2006; 149(4):468-474 |
Publisher: | Mosby Inc |
Issue Date: | 2006 |
ISSN: | 0022-3476 1097-6833 |
Abstract: | <h4>Objective</h4>To evaluate the effect of baclofen, a gamma-amino-butyric-acid B receptor agonist that inhibits transient lower esophageal sphincter relaxation (TLESR), on the rates of TLESR, gastroesophageal reflux (GER), and gastric emptying (GE) in children with GER disease.<h4>Study design</h4>The efficacy of 0.5 mg/kg baclofen was evaluated in a randomized, double-blinded, placebo-controlled trial in 30 children. Patients were intubated with a manometric/pH assembly and given 250 mL of cow's milk. Esophageal motility and pH were then measured for 2 hours (control period). Baclofen or placebo was then administered, and 1 hour later 250 mL of milk was given again and measurements performed for another 2 hours (test period). The GE rate was measured by the (13)C octanoate breath test.<h4>Results</h4>Baclofen significantly reduced the incidence of TLESR (mean, 7.3 +/- 1.5 vs 3.6 +/- 1.2 TLESR/2 hours; P < .05) and acid GER (mean 4.2 +/- 0.7 vs 1.7 +/- 1.0 TLESR + GER/2 hours; P < .05) during the test period compared with the control period. Baclofen significantly accelerated the GE rate (median [interquartile range], GE(t1/2), 61 minutes [39, 81 minutes] vs 114 minutes [67, 170 minutes]; P < .05). Baclofen had no effect on the swallowing rate, pattern of esophageal peristalsis, or lower esophageal sphincter pressure.<h4>Conclusions</h4>Baclofen reduces GER in children by inhibiting the triggering of TLESR. Baclofen also accelerates GE. |
Keywords: | Humans Gastroesophageal Reflux Baclofen GABA Agonists Double-Blind Method Gastrointestinal Motility Adolescent Child Child, Preschool Female Male |
DOI: | 10.1016/j.jpeds.2006.05.029 |
Published version: | http://dx.doi.org/10.1016/j.jpeds.2006.05.029 |
Appears in Collections: | Aurora harvest 6 Paediatrics publications |
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