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Type: Journal article
Title: Th2 immunological inflammation in allergic fungal sinusitis, nonallergic eosinophilic fungal sinusitis, and chronic rhinosinusitis
Author: Carney, A.
Tan, L.
Adams, D.
Varelias, A.
Ooi, E.
Wormald, P.
Citation: American Journal of Rhinology and Allergy, 2006; 20(2):145-149
Publisher: Ocean Side Publications Inc
Issue Date: 2006
ISSN: 1945-8924
Statement of
Carney, A. Simon; Tan, Lor-Wai; Adams, Damian; Varelias, Antiopi; Ooi, Eng Hooi; Wormald, Peter-John
Abstract: <h4>Background</h4>Noninvasive fungal sinusitis is a heterogenous group of conditions including allergic fungal sinusitis (AFS) and nonallergic eosinophilic fungal sinusitis (NEFS). Th2-mediated cascades have been postulated to be the major inflammatory response in patients with AFS although other mechanisms also may be involved. The detailed mucosal Th2 cytological status of NEFS still has not been studied in great depth.<h4>Methods</h4>Using a meticulous patient selection algorithm over a 2-year period, infundibular mucosal tissue from patients with AFS, NEFS, chronic rhinosinusitis (CRS), and normal controls was studied (n = 59). Immunohistochemistry for mast cells, eosinophils, and immunoglobulin E (IgE) cells was performed and cell counts per unit area were measured.<h4>Results</h4>Mast cell, eosinophil, and IgE+ cell numbers were significantly raised in patients with AFS, NEFS, and CRS when compared with controls. There was no significant difference between cell numbers in patients with AFS and NEFS.<h4>Conclusion</h4>Patients with AFS exhibit a classic Th2 inflammatory response in nasal mucosal tissue with NEFS and CRS patients showing evidence of a similar Th2 cascade, including the presence of IgE+ cells.
Keywords: Nasal Mucosa
Th2 Cells
Mast Cells
Respiratory Hypersensitivity
Chronic Disease
Immunoglobulin E
Cell Count
Case-Control Studies
Middle Aged
DOI: 10.1177/194589240602000204
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