Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Th2 immunological inflammation in allergic fungal sinusitis, nonallergic eosinophilic fungal sinusitis, and chronic rhinosinusitis|
|Citation:||American Journal of Rhinology & Allergy, 2006; 20(2):145-149|
|Publisher:||Ocean Side Publications Inc|
|Carney, A. Simon; Tan, Lor-Wai; Adams, Damian; Varelias, Antiopi; Ooi, Eng Hooi; Wormald, Peter-John|
|Abstract:||<h4>Background</h4>Noninvasive fungal sinusitis is a heterogenous group of conditions including allergic fungal sinusitis (AFS) and nonallergic eosinophilic fungal sinusitis (NEFS). Th2-mediated cascades have been postulated to be the major inflammatory response in patients with AFS although other mechanisms also may be involved. The detailed mucosal Th2 cytological status of NEFS still has not been studied in great depth.<h4>Methods</h4>Using a meticulous patient selection algorithm over a 2-year period, infundibular mucosal tissue from patients with AFS, NEFS, chronic rhinosinusitis (CRS), and normal controls was studied (n = 59). Immunohistochemistry for mast cells, eosinophils, and immunoglobulin E (IgE) cells was performed and cell counts per unit area were measured.<h4>Results</h4>Mast cell, eosinophil, and IgE+ cell numbers were significantly raised in patients with AFS, NEFS, and CRS when compared with controls. There was no significant difference between cell numbers in patients with AFS and NEFS.<h4>Conclusion</h4>Patients with AFS exhibit a classic Th2 inflammatory response in nasal mucosal tissue with NEFS and CRS patients showing evidence of a similar Th2 cascade, including the presence of IgE+ cells.|
|Keywords:||Nasal Mucosa; Eosinophils; Th2 Cells; Mast Cells; Humans; Mycoses; Sinusitis; Rhinitis; Respiratory Hypersensitivity; Eosinophilia; Chronic Disease; Immunoglobulin E; Cell Count; Immunohistochemistry; Case-Control Studies; Adolescent; Adult; Aged; Middle Aged|
|Appears in Collections:||Medicine publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.