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Type: Journal article
Title: A system for improving vitamin D nutrition in residential care
Author: Wigg, A.
Prest, C.
Slobodian, P.
Need, A.
Cleland, L.
Citation: Medical Journal of Australia, 2006; 185(4):195-198
Publisher: Australasian Med Publ Co Ltd
Issue Date: 2006
ISSN: 0025-729X
Statement of
Alison E R Wigg, Caroline Prest, Peter Slobodian, Allan G Need and Leslie G Cleland
Abstract: Objective: To assess the feasibility of administering an inexpensive preparation of vitamin D3 100 000 IU orally 3 monthly to aged-care residents. Design: Prospective, controlled open-label implementation trial. Setting: Residential aged care, November 2003 to May 2004 (primary study). Participants: 137 ambulant residents: 107 treated (mean age, 85 years; 79 were women), 30 untreated controls (mean age, 87 years; 22 were women). Interventions: Lactose microencapsulated vitamin D3 100 000 IU orally at baseline, then 3 monthly (three or more doses); untreated subjects were observed contemporaneously. Main outcome measures: Serum levels of 25-hydroxyvitamin D [25(OH)D] at 6 months compared with baseline; acceptability of the program to residents and staff. Results: At baseline, 95% of residents assessed (n = 137) had serum 25(OH)D levels below the desirable range of 60–160 nmol/L. At 6 months, all treated residents (n = 98) achieved desired levels, with the mean (± SD) 25(OH)D level increasing from 36.4 ± 12.6 nmol/L (range, 12–75 nmol/L) at baseline to 124.0 ± 27.9 nmol/L (range, 68–244 nmol/L). In no resident did 25(OH)D approach toxic levels. The mean serum 25(OH)D level remained low in the control group (n = 27): 42.8 ± 18.3 nmol/L (range, 18–98 nmol/L). The difference between the mean 25(OH)D levels of treatment and control groups at 6 months was 81.2 nmol/L (95% CI, 69.7–92.0 nmol/L). The cost of the supplement was $4 per resident per annum. Substudies showed mean trough serum 25(OH)D levels in the desired range at 3 months (n = 31), but below the desired range at 6 months (n = 50). Subjects given 3-monthly doses for up to 2 years maintained serum 25(OH)D levels within the desired range, with no trend toward undesirable accumulation (n = 11). Conclusions: Vitamin D3 100 000 IU given orally 3 monthly is a practical, safe, effective and inexpensive way to meet the vitamin D3 requirements of aged-care residents.
Keywords: Humans; Vitamin D Deficiency; Cholecalciferol; Vitamin D; Administration, Oral; Prospective Studies; Feasibility Studies; Aged; Aged, 80 and over; Homes for the Aged; Female; Male; Surveys and Questionnaires
Description: The document attached has been archived with permission from the editor of the Medical Journal of Australia. An external link to the publisher’s copy is included.
RMID: 0020061234
DOI: 10.5694/j.1326-5377.2006.tb00530.x
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