Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/28060
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Type: Journal article
Title: Conservation of a DPP/BMP signaling pathway in the nonbilateral cnidarian Acropora millepora
Author: Samuel, G.
Miller, D.
Saint, R.
Citation: Evolution and Development, 2001; 3(4):241-250
Publisher: Blackwell Science Inc
Issue Date: 2001
ISSN: 1520-541X
1525-142X
Organisation: Centre for the Molecular Genetics of Development
Abstract: Members of the TGF-╬▓ superfamily of signaling molecules are widespread in metazoans, but the evolutionary origin of particular subclasses of signaling mechanisms is poorly defined. The DPP/BMP class, for example, is implicated in dorsal-ventral patterning, neural patterning, and limb development. Here we report the presence of several components of a DPP/BMP-specific signal transduction cascade in a nonbilateral animal, the coral Acropora millepora. The discovery of these components, a putative type I receptor and two putative receptor-activated Smads, suggests that DPP/BMP signaling predates both dorsal-ventral pattern formation and limb development. We postulate that an ancestral role in neuroepithelial patterning may account for the high level of conservation between DPP/BMP signaling components found in this nonbilateral animal and the more complex triploblastic organisms of the arthropod and chordate phyla.
Keywords: Animals
Cnidaria
Transforming Growth Factor beta
DNA-Binding Proteins
Trans-Activators
Bone Morphogenetic Proteins
Phosphoproteins
DNA, Complementary
Cloning, Molecular
Evolution, Molecular
Phylogeny
Signal Transduction
Amino Acid Sequence
Base Sequence
Conserved Sequence
Sequence Homology, Amino Acid
Gene Library
Molecular Sequence Data
Smad Proteins
Smad5 Protein
Biological Evolution
Description: The definitive version may be found at www.wiley.com
DOI: 10.1046/j.1525-142x.2001.003004241.x
Appears in Collections:Aurora harvest 2
Centre for the Molecular Genetics of Development publications
Molecular and Biomedical Science publications

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