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Type: Journal article
Title: A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors
Author: Andersson, P.
McGuire, J.
Rubio, C.
Gradin, K.
Whitelaw, M.
Pettersson, S.
Hanberg, A.
Poellinger, L.
Citation: Proceedings of the National Academy of Sciences of USA, 2002; 99(15):9990-9995
Publisher: Natl Acad Sciences
Issue Date: 2002
ISSN: 0027-8424
Organisation: Centre for the Molecular Genetics of Development
Statement of
Patrik Andersson, Jacqueline McGuire, Carlos Rubio, Katarina Gradin, Murray L. Whitelaw, Sven Pettersson, Annika Hanberg, and Lorenz Poellinger
Abstract: The dioxin/aryl hydrocarbon receptor (AhR) functions as a ligand-activated transcription factor regulating transcription of a battery of genes encoding xenobiotic metabolizing enzymes. Known receptor ligands are environmental pollutants including polycyclic aromatic hydrocarbons and polychlorinated dioxins. Loss-of-function (gene-disruption) studies in mice have demonstrated that the AhR is involved in toxic effects of dioxins but have not yielded unequivocal results concerning the physiological function of the receptor. Gain-of-function studies therefore were performed to unravel the biological functions of the AhR. A constitutively active AhR expressed in transgenic mice reduced the life span of the mice and induced tumors in the glandular part of the stomach, demonstrating the oncogenic potential of the AhR and implicating the receptor in regulation of cell proliferation.
Keywords: Liver
Thymus Gland
CHO Cells
Mice, Inbred C57BL
Mice, Inbred CBA
Intestinal Neoplasms
Stomach Neoplasms
Cytochrome P-450 CYP1A1
Receptors, Aryl Hydrocarbon
Recombinant Proteins
Cloning, Molecular
Gene Expression Regulation, Developmental
Polychlorinated Dibenzodioxins
Description: Published online before print July 9, 2002
Rights: Copyright © 2002 by the National Academy of Sciences
DOI: 10.1073/pnas.152706299
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Appears in Collections:Aurora harvest 2
Centre for the Molecular Genetics of Development publications
Molecular and Biomedical Science publications

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