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Type: Conference item
Title: Upregulation of neuronal amyloid precursor protein (APP) and APP mRNA following magnesium sulphate (MgSO4) therapy in traumatic brain injury
Author: Van Den Heuvel, C.
Finnie, J.
Blumbergs, P.
Manavis, J.
Jones, N.
Reilly, P.
Pereira, R.
Citation: Abstracts of the 5th International Neurotrauma Symposium, 2000: pp.238
Publisher: IOS Press
Publisher Place: Amsterdam, The Netherlands
Issue Date: 2000
ISSN: 0897-7151
Conference Name: International Neurotrauma Symposium (5th : 2000 : Garmisch-Partenkirchen, Germany)
Editor: Sabel, B.
Abstract: The aim of this study was to assess and quantitate topographically the effects of posttraumatic intravenous magnesium sulphate (MgSO4) on neuronal perikaryal APP antigen and messenger RNA (mRNA) expression in sheep brains 2 h after a controlled focal head impact. The percentage brain area with APP immunoreactive neuronal perikarya was 71, 56, 27.5 and 5.5%, respectively, in MgSO4-treated head-injured animals, head-injured animals without any treatment, MgSO4 treated nonimpacted animals, and nontreated nonimpacted control sheep. Although there was no statistically significant difference in APP immunoreactive neuronal perikarya in the MgSO4-treated HI group (mean 71%) compared to the HI group without any treatment (mean 56%), northern analysis showed that there was a 2.3-+/-0.2-fold increase in APP mRNA in the thalamus of treated impacted animals compared to untreated impacted animals (p < 0.005). However, MgSO4 treated nonimpacted control animals also showed a 1.6-+/-0.1-fold increase in APP mRNA compared to untreated nonimpacted controls (p < 0.005). MgSO4 therapy results in upregulation of neuronal APP mRNA and APP expression that is quantitatively greater following a focal head impact.
Keywords: Neurons
Brain Injuries
Magnesium Sulfate
Amyloid beta-Protein Precursor
Blotting, Northern
In Situ Hybridization
Description: Poster session 7: Neurotrauma models 2, Paper P230 Also cited as - Restorative Neurology and Neuroscience, 2000; 16(3-4):238
Rights: © 2000, IOS Press
DOI: 10.1089/neu.2000.17.1041
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Pathology publications

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