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|Title:||Ketanserin in women with chronic hypertension and underlying thrombophilia|
van Geijn, H.
|Citation:||Obstetrics and Gynecology, 2004; 103(5):1084-1087|
|Publisher:||Lippincott Williams & Wilkins|
|Franyke R.Banga, Antoinette C. Bolte, Gustaaf A. Dekker, Herman P. van Geijn|
|Abstract:||BACKGROUND: Pregnant women with chronic hypertension and thrombophilia have an increased risk for preeclampsia and/or intrauterine growth restriction (IUGR). Ketanserin lowers blood pressure and inhibits serotonin-induced platelet aggregation. CASES: A 38-year-old woman with chronic hypertension had a first pregnancy with severe hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome. A second pregnancy with prophylactic oral ketanserin and low-dose aspirin was uneventful. The third pregnancy without oral ketanserin was again complicated by severe superimposed preeclampsia and IUGR. During this pregnancy a prothrombin mutation was found. A 37-year-old woman with chronic hypertension developed severe early-onset superimposed preeclampsia in her first pregnancy. In the 3 consecutive pregnancies, she was treated with low-molecular-weight heparin because of a factor XII deficiency. Only the pregnancy with the use of prophylactic oral ketanserin was uncomplicated. CONCLUSION: Clinical trials are warranted to analyze the role of oral ketanserin in preventing preeclampsia and IUGR.|
|Keywords:||Humans; Pregnancy Complications; Fetal Growth Retardation; HELLP Syndrome; Pre-Eclampsia; Hypertension; Thrombophilia; Ketanserin; Antihypertensive Agents; Pregnancy; Adult; Female|
|Rights:||© 2004 The American College of Obstetricians and Gynecologists|
|Appears in Collections:||Obstetrics and Gynaecology publications|
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