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Type: Journal article
Title: Ketanserin in women with chronic hypertension and underlying thrombophilia
Author: Banga, F.
Bolte, A.
Dekker, G.
van Geijn, H.
Citation: Obstetrics and Gynecology, 2004; 103(5):1084-1087
Publisher: Lippincott Williams & Wilkins
Issue Date: 2004
ISSN: 0029-7844
Statement of
Franyke R.Banga, Antoinette C. Bolte, Gustaaf A. Dekker, Herman P. van Geijn
Abstract: BACKGROUND: Pregnant women with chronic hypertension and thrombophilia have an increased risk for preeclampsia and/or intrauterine growth restriction (IUGR). Ketanserin lowers blood pressure and inhibits serotonin-induced platelet aggregation. CASES: A 38-year-old woman with chronic hypertension had a first pregnancy with severe hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome. A second pregnancy with prophylactic oral ketanserin and low-dose aspirin was uneventful. The third pregnancy without oral ketanserin was again complicated by severe superimposed preeclampsia and IUGR. During this pregnancy a prothrombin mutation was found. A 37-year-old woman with chronic hypertension developed severe early-onset superimposed preeclampsia in her first pregnancy. In the 3 consecutive pregnancies, she was treated with low-molecular-weight heparin because of a factor XII deficiency. Only the pregnancy with the use of prophylactic oral ketanserin was uncomplicated. CONCLUSION: Clinical trials are warranted to analyze the role of oral ketanserin in preventing preeclampsia and IUGR.
Keywords: Humans; Pregnancy Complications; Fetal Growth Retardation; HELLP Syndrome; Pre-Eclampsia; Hypertension; Thrombophilia; Ketanserin; Antihypertensive Agents; Pregnancy; Adult; Female
Rights: © 2004 The American College of Obstetricians and Gynecologists
RMID: 0020042583
DOI: 10.1097/01.AOG.0000117085.65925.f2
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Appears in Collections:Obstetrics and Gynaecology publications

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