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Type: Journal article
Title: Immunoglobulin kappa light chain gene alleles are not associated with primary Sjogren's Syndrome
Author: Downie-Doyle, S.
Lester, S.
Bardy, P.
Gordon, T.
Rischmueller, M.
Pile, K.
Citation: Genes and Immunity, 2002; 3(Suppl 1):S63-S65
Publisher: Nature Publishing Group
Issue Date: 2002
ISSN: 1466-4879
Statement of
S Downie-Doyle, S Lester, P Bardy, T Gordon, M Rischmueller and K Pile
Abstract: The immunoglobulin kappa (Km) light chain gene is polymorphic and is believed to play a role in the pathology of infectious and autoimmune diseases. Polymorphisms within the constant region of the Km gene encode three alleles designated Km1, Km1,2 and Km3. Previous studies using serological detection of Km allotypes reported associations between specific Km allotypes, systemic lupus erythematosus and the presence of anti-La antibodies, yet these findings were not confirmed in other studies. In order to more precisely define any associations between Km alleles and anti-Ro/La antibodies we used the polymerase chain reaction and restriction fragment length polymorphisms for Km genotyping in a large cohort of patients with primary Sjögren’s syndrome (SS). No associations were observed between specific Km alleles and primary SS when compared with a control population, nor within serologically defined subsets of SS patients. We conclude that Km alleles are not associated with primary SS or the Ro/La autoantibody response.
Keywords: immunoglobulins; Sjögren’s syndrome; Km allotypes; polymorphism
Rights: © 2002 Nature Publishing Group
RMID: 0020021373
DOI: 10.1038/sj.gene.6363853
Appears in Collections:Medicine publications

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