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|Title:||An enhanced linkage map of the sheep genome comprising more than 1000 loci|
van Stijn, T.
|Citation:||Genome Research, 2001; 11(7):1275-1289|
|Publisher:||Cold Spring Harbor Lab Press|
|Jillian F. Maddox, Kizanne P. Davies, Allan M. Crawford, Dennis J. Hulme, Daniel Vaiman, Edmond P. Cribiu, Bradley A. Freking, Ken J. Beh, Noelle E. Cockett, Nina Kang, Christopher D. Riffkin, Roger Drinkwater, Stephen S. Moore, Ken G. Dodds, Joanne M. Lumsden, Tracey C. van Stijn, Sin H. Phua, David L. Adelson, Heather R. Burkin, Judith E. Broom, Johannes Buitkamp, Lisa Cambridge, William T. Cushwa, Emily Gerard, Susan M. Galloway, Blair Harrison, Rachel J. Hawken, Stefan Hiendleder, Hannah M. Henry, Juan F. Medrano, Korena A. Paterson, Laurent Schibler, Roger T. Stone, and Beryl van Hest|
|Abstract:||A medium-density linkage map of the ovine genome has been developed. Marker data for 550 new loci were generated and merged with the previous sheep linkage map. The new map comprises 1093 markers representing 1062 unique loci (941 anonymous loci, 121 genes) and spans 3500 cM (sex-averaged) for the autosomes and 132 cM (female) on the X chromosome. There is an average spacing of 3.4 cM between autosomal loci and 8.3 cM between highly polymorphic [polymorphic information content (PIC) 0.7] autosomal loci. The largest gap between markers is 32.5 cM, and the number of gaps of >20 cM between loci, or regions where loci are missing from chromosome ends, has been reduced from 40 in the previous map to 6. Five hundred and seventy-three of the loci can be ordered on a framework map with odds of >1000 : 1. The sheep linkage map contains strong links to both the cattle and goat maps. Five hundred and seventy-two of the loci positioned on the sheep linkage map have also been mapped by linkage analysis in cattle, and 209 of the loci mapped on the sheep linkage map have also been placed on the goat linkage map. Inspection of ruminant linkage maps indicates that the genomic coverage by the current sheep linkage map is comparable to that of the available cattle maps. The sheep map provides a valuable resource to the international sheep, cattle, and goat gene mapping community.|
|Keywords:||Animals; Cattle; Sheep; Genetic Markers; Chromosome Mapping; Meiosis; Microsatellite Repeats; Minisatellite Repeats; Genotype; Polymorphism, Restriction Fragment Length; Genome; Female; Male; Genetic Linkage|
|Appears in Collections:||Agriculture, Food and Wine publications|
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